OBJECTIVE To determine the prevalence of congenital hypothyroidism (CH), permanent and transient CH. METHODS From November 2006 to September 2007, 63031 newborns were screened by measuring serum TSH obtained by heel prick. The neonates who had a TSH≥5mU/L were recalled for measurement of serum T(4), thyroid stimulating hormone (TSH) and TSH receptor blocking antibodies (TRBAb) in venous sampl...

BACKGROUND Congenital hypothyroidism is a condition of thyroid hormone deficiency. Approximately 1 in 4000 newborn infants has a deficiency of thyroid function. The aim of this study is determination of the prevalence of permanent and transient congenital hypothyroidism (CH) in Yazd, Iran. METHODS From May 2006 to June 2008, 35377 newborns were screened by measuring serum TSH obtained by heel...

The observation of Campbell and Price in 1979 that their Unit had diagnosed four subjects with both Klinefelter's syndrome and congenital hypothyroidism raised the suspicion of an association between the two conditions. This, and the published reports of an XX male, five XXY males, and one mosaic XY/XXY with congenital or acquired forms of hypothyroidism, together with the higher incidence in w...

Seven of the 34 infants identified through the Welsh Hypothyroid Screening Programme have additional congenital abnormalities. Two infants have a previously undescribed syndrome, two have chromosomal abnormalities, two have congenital heart disease, and one has a myelomeningocoele. Congenital hypothyroidism often seems to be associated with other congenital abnormalities.

Congenital hypothyroidism is one of the causes mental retardation in children that can be prevented if recognized and treated early. Thyroid hormones play a role development central nervous system. It known 95% CH do not show typical clinical signs symptoms at birth duration early intervention to prevent short. Therefore, most developed countries have conducted neonatal screening programs for d...