BACKGROUND The development of therapies for psoriasis has led to the need for a new strategy to the treatment of patients with moderate-to-severe psoriasis. New consensus guidelines for psoriasis treatment have been developed in some countries, some of which have introduced treatment goals to determine the timing of therapeutic regimens for psoriasis. OBJECTIVE To investigate the opinions hel...

One of the corner stones of formal methods is the notion that abstraction enables analysis. By the construction of an abstract model we can trade implementation detail for analytical power. The intent of a model is to preserve selected characteristics of real-world artifact, while suppressing others. Unfortunately, practitioners are less likely to use a modeling tool if it cannot handle realwor...

..................................................................................................................xi 1 Background: Creating the Colloquium ..........................................................1 1.1 The Field Study .........................................................................................1 1.2 The Discovery Colloquium..............................................

BACKGROUND Clinical practice guidelines should be based on the best available evidence. However, this evidence is often incomplete, controversial, or lacking. Other considerations beyond the evidence are therefore needed to be able to formulate specific and applicable recommendations for clinical practice. OBJECTIVE The aim of this study is to obtain consensus among experts about a set of dom...

We look at the main issue of the Colloquium \Formal Methods at the Crossroads from Panacea to Foundational Support" reeecting on our rather long experience of active engagement in the development and use of formal techniques. In the years, we have become convinced of the necessity of an approach more concerned with the real needs of the software development practice. Consequently, we have shift...

Major industrial and governmental efforts in information sharing and integration require building or migrating applications using heterogeneous component systems. This style of software development enjoys the benefits of reusability, adaptability, and evolvability. However, as with most component integration attempts, interoperability problems arise. Although there are several strategies that c...

The UniForM Workbench supports combination of Formal Methods (on a solid logical foundation), provides tools for the development of hybrid, real-time or reactive systems, transformation, verification, validation and testing. Moreover, it comprises a universal framework for the integration of methods and tools in a common development environment. Several industrial case studies are described.

We now are starting to see the first applications of formal methods to the development of safety critical based systems. However, discussion on what are appropriate methods and tools is still intense and there is no standard approach that presents a complete solution for the formal development of such systems. Some of the protagonists claim (or at least are said to claim by their detractors) th...

0018-9162/06/$20.00 © 2006 IEEE 40 Computer P u b l i s h e d b y t h e I E E E C o m p u t e r S o c i e t y Real engineers use mathematics. Formal methods are the mathematics of software engineering. Therefore, software engineers should use formal methods. Yet even with this elegant simplicity, most projects hold formal methods at arm’s length unless they involve the design and maintenance of...

The availability of information is a key success factor for effective Concurrent Engineering (CE). However, in day-to-day practice, missing information is the bottleneck in many product development projects. One of the major reasons for this is the insufficient planning of information and communication structures (ICS). Within the scope of a CE research project, from which different methods and...