BACKGROUND AND OBJECTIVE Heated, humidified high-flow nasal cannula (HHHFNC) is commonly used as a noninvasive mode of respiratory support in the NICU. The safety and efficacy of HHHFNC have not been compared with other modes of noninvasive support in large randomized trials. The objective was to assess the efficacy and safety of HHHFNC compared with nasal continuous positive airway pressure (n...

We consider a non-homogeneous continuous time Markov chain model for Long-Term Care with five states: the autonomous state, three dependent states of light, moderate and severe dependence levels death state. For general approach, we allow non null intensities all returns from higher to lesser dependencies in multi-state model. Using data 2015 Portuguese National Network Continuous database, as ...