conclusions midazolam/meperidine and propofol sedation for colonoscopy have similar cardiopulmonary safety profiles and patient satisfaction levels. midazolam/meperidine can be preferred to propofol sedation due to a shorter hospital length of stay and better analgesic activity. the patient satisfaction rates were not significantly different between the groups; however, patients in the propofol...

objective: we conducted a double-blind, placebo-controlled study to determine the efficacy of an herbal sexual supplement (vigrx) on premature ejaculation (pe). method: a randomized double blind study was conducted on a fixed dose of herbal vigrx at roozbeh psychiatry hospital, tehran university of medical sciences. the sample consisted of 85 married patients diagnosed with primary pe according...

objective(s): in this research, zeolite x and zeolite y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. materials and methods: a soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. gravimetric methods and ir spectra of prepared formulations were used to assess drug loading efficiencies into...

Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...

Objective(s): Colorectal cancer (CRC) is a prevalent cancer worldwide. The present study aimed to synthesize and investigate the potential of wheat germ agglutinin (WGA) conjugated with polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) incorporating 5-fluorouracil (5-FU). Materials and Methods: The NPs were investigated in terms of various characteristics, such as the particle size, ...

Imaging ellipsometry was combined with electrochemical methods for studying electrostatic interactions of protein and solid surfaces. The potential of zero charge for gold-coated silicon wafer/solution interfaces wad determined by AC impedance method. The potential of the gold-coated silicon wafer was controlled at the potential of zero charge, and the adsorption of fibrinogen on the potential-...