Sir,—May I offer some comments on the article by Drury and Gilbertson? (Brir. J. Anaesth. (1970), 42, 1021). (1) A likely cause of the hyperpyrexia is the combination of pediidine and atropine in conjunction with anaesthesia. Pediidine potentiates atropine and probably atropine potentiates pethidine. Pethidine is not needed for premedication, and probably can be dispensed with safely. (2) It is...