نتایج جستجو برای: copy number typing

تعداد نتایج: 1213843  

Journal: :European Journal of Human Genetics 2007

Journal: :Nature Reviews Genetics 2009

Journal: :Cytogenetic and genome research 2008
H Auer

DNA copy number variation (CNV) was recently discovered as a significant part of human genetic variation. This variation affects genes as well as intergenic regions. Herein, current insight into the effects of CNV on gene expression is summarized. The consequences of intergenic CNVs are poorly understood. For CNV affecting genes, a dosage compensation mechanism seems to be applied on a subset o...

2016
Chen Chi Rasif Ajwad Qin Kuang Pingzhao Hu

Many cancers have been linked to copy number variations (CNVs) in the genomic DNA. Although there are existing methods to analyze CNVs from individual samples, cancer-causing genes are more frequently discovered in regions where CNVs are common among tumor samples, also known as recurrent CNVs. Integrating multiple samples and locating recurrent CNV regions remain a challenge, both computationa...

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