Aicardi syndrome is a severe congenital disorder characterised by infantile spasms, chorioretinal lacunae, and agenesis ofthe corpus callosum. We present the case of a 10-year-old girl whose symptoms included a poorly controlled seizure disorder, typical lacunar retinopathy, partial hypoplasia of the corpus callosum, and mild developmental delay. This case alerts ophthalmologists to the presenc...

The development of the corpus callosum depends on a large number of different cellular and molecular mechanisms. These include the formation of midline glial populations, and the expression of specific molecules required to guide callosal axons as they cross the midline. An additional mechanism used by callosal axons from neurons in the neocortex is to grow within the pathway formed by pioneeri...

A three locus model of the inheritance of absent corpus callosum in mice was tested by creating F1 and F2 hybrid crosses from the strains BALB/cWah1 and 129/J which show incomplete penetrance for callosal agenesis. The model predicted that a few of the F2 hybrid mice would suffer severe reduction of the hippocampal commissure when the corpus callosum was absent, a condition that usually occurs ...