Recent requirements to establish the credibility of the models and simulations (M&S) that are used in Department of Defense (DoD) applications have resulted in the development of several approaches to M&S credibility assessment. Each of these approaches attempts to integrate verification and validation (V&V) activities into a formal process whose products (hopefully) support M&S accreditation. ...

To the Editor The authors of the article, “Decision-Making Analysis for Allergen Immunotherapy versus Nasal Steroids in the Treatment of Nasal Steroid-Responsive Allergic Rhinitis,” must be commended, because they introduce an original approach to assess the costeffectiveness of subcutaneous immunotherapy (SCIT).1 It is a pity that they did not take into account also sublingual immunotherapy (S...

Background: Vaccination against HPV presents a new primary prevention strategy against cervical cancer and is now being introduced in countries all over Europe. Health-economic modelling plays an increasingly important role in the decision making process when introducing new health-care technologies into national programmes. This study compares the economic evaluations used by European countrie...

A cost utility analysis and budget impact (BI) were developed using a decision model to compare the incremental outcomes and costs of monitoring the depth of anaesthesia with BIS monitors compared with using clinical signs, electrocardiography (ECG) and other devices (standard clinical monitoring) over a five-year period. The health outcomes included are utility values associated with adverse e...

We greatly appreciate the comments of Dr. Rutte et al. regarding our recent study on the effectiveness of sexual counseling models in health care [1]. We agree with them that to find a more cost-effective alternative for standard models, such as Permission, Limited Information, Specific Suggestions, and Intensive Therapy (PLISSIT), we should perform a costeffectiveness study. We will need furth...