The gene for cholesterol 7 a -hydroxylase ( CYP7A1 ) contains a sequence at nt 2 149 to 2 118 that was found to play a large role in determining the overall transcriptional activity and regulation of the promoter. Hepatocyte nuclear factor 4 (HNF4) and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) synergistically activate transcription of the CYP7A1 promoter. Transacti...

The deposition of a basement membrane by primitive endoderm cells is necessary for polarization of the epiblast and formation of the proamniotic cavity in periimplantation mammalian embryos. The synthesis of this basement membrane is in turn dependent upon laminin expression. Here we have used embryoid bodies derived from mouse embryonic stem cells to investigate the molecular mechanisms contro...

The liver consists of different cell types that together synchronize crucial roles in liver homeostasis. Since nuclear receptors constitute an important class of drug targets that are involved in a wide variety of physiological processes, we have composed the hepatic cell type-specific expression profile of nuclear receptors to uncover the pharmacological potential of liver-enriched nuclear rec...

Cardiac expression of genes involved in fatty acid metabolism may suffer alterations depending on the substrate availability. We studied how troglitazone, an antidiabetic drug that selectively activates peroxisome proliferator-activated receptor gamma (PPARgamma), affected the expression of several of these genes. A single-day troglitazone administration (100 mg/kg/day) did not significantly al...

Abstract The term “coup” has been used to describe a diverse range of events. Although recent decades have seen the academic study coups focus on an increasingly narrow type military intervention in politics, general public, governments, and international organizations frequently apply coup label broader set antidemocratic actions. This was dramatically illustrated after overrunning US Capitol ...

Conflict and civil wars are ongoing in Myanmar. Internal displaced persons of Rohingya now more than one million people, according to United Nations. Even during the COVID-19 pandemic, Myanmar government continue using military approaches against its especially after coup. This article will elaborates on condition pandemic amid conflicts coups. It is essential see how these three phenomena repr...

Abstract Regime change often exacerbates ethnic conflict. This article examines the curious case of Myanmar, where a 2021 military coup was met, on surface, with broad-based resistance across divided society. An important question that therefore arises is whether, below this unity also took more positive form national solidarity. Were deep cleavages intensified or alleviated by coup? bears theo...