Abstract Background Immune checkpoint inhibitors (CPI) have revolutionised cancer treatment, with previously untreatable disease now amenable to potential cure. Combination regimens of anti-CTLA4 and anti-PD-1 show enhanced efficacy but are prone off target immune-mediated tissue injury, particularly at the barrier surfaces. CPI-induced colitis is a common serious complication. Methods To probe...

Distributed applications have fostered the standardization of application programming interfaces for the underlying communication services. Three popular communication modelsremote procedure calls, messaging and queuing, and conversations-support distributed applications across different networking protocols and physical media. Access to the conversational services of Advanced Programto-Program...

We analyze the dependence of the Gross Domestic Product (GDP ) per capita growth rates on changes in the Corruption Perceptions Index (CPI). For the period 1999–2004 for all countries in the world, we find on average that an increase of CPI by one unit leads to an increase of the annual GDP per capita growth rate by 1.7%. By regressing only the European countries with transition economies, we f...

To assess overall and abdominal obesity and their relation to periodontal disease among young adults, body mass index (BMI) and waist circumference (WC) were measured and clinical attachment loss (CAL), gingival index (GI) and Community Periodontal Index (CPI) were estimated. The sample comprised 380 adults (170 males and 210 females) aged 20-26 years. There was a significant correlation betwee...

Beneficiaries of the Old-Age, Survivors, and Disability Insurance (OASDI) program received an 11.2-percent cost-of-living increase in benefits effective June 1981. This increase, the seventh automatic increase since 1975, was reflected in btiefit checks issued early in July. Automatic benefit increases are tied by statute to rises in the Consumer Price Index (CPI). They are initiated whenever t...

Department of Electrical & Electronic Engineering The University of Hong Kong Pokfulam Road, HONG KONG * Email : [email protected] Email : [email protected] ** In this paper, a new Corrupted-Pixel-Identification (CPI) based estimation filter is presented. The method is especially useful for filtering clustered noise. After the corrupted pixels are identified by the CPI algorithm, the noisy ...

Several neuroimaging studies have suggested that brain impairment and plasticity occur in patients with chronic primary insomnia (CPI); however, the effects of insomnia on the intrinsic organization of the brain remain largely unknown. In this study, a voxel-based functional connectivity strength (FCS) assessment, a data-driven method based on a theoretical approach, was applied to investigate ...

Crystal structures of CYP2B35 and CYP2B37 from the desert woodrat were solved in complex with 4-(4-chlorophenyl)imidazole (4-CPI). The closed conformation of CYP2B35 contained two molecules of 4-CPI within the active site, whereas the CYP2B37 structure demonstrated an open conformation with three 4-CPI molecules, one within the active site and the other two in the substrate access channel. To p...