RATIONALE Craniosynostosis is a disorder characterized by premature fusion of cranial sutures with subsequent development of abnormal craniofacial contour associated with variable skeletal and extra-skeletal abnormalities. In this family syndromic type of craniosynostosis was recognized and the etiology behind diverse forms of deformities have been diagnosed. PATIENT CONCERNS The negative imp...

OBJECTIVE Craniofacial deformities (CFDs) frequently accompany midfacial hypoplasia. The authors evaluated characteristics of maxillary sinuses that had CFDs with variable degrees of midfacial hypoplasia. STUDY DESIGN Cross-sectional survey with chart review. SETTING Department of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic ...

Modulation of the immune system as an approach to attack cancer has been explored for the past 50 years. Efficacy of this treatment has been achieved in a limited number of patients. However, a major obstacle of immune therapy is the toxicity related to the nonspecific nature of immune activation. Efforts to improve the specificity of the immune response have been investigated through the use o...

A Survey on the incidence of congenital malformations of the ruminants was conducted from Jan. 2001 – April 2002. The specimens collected were grossly examined and either dissected or radiographed. A total of 11 cases of malformations were recorded, out of which 5 (45.5%) were of ovine species, 4 (36.4%) cases from caprine and 2 cases (18.2%) were from bovine species. Seven of the cases were fo...

Recent advances in medical imaging and surgical techniques have made possible the correction of severe facial deformities and fractures. Surgical correction techniques often involve the direct manipulation - both relocation and surgical fracture - of the underlying facial bone. The work presented here introduces an environment for interactive, visuohaptic simulation of craniofacial surgical pro...

Hemoproteins are critical for the function and integrity of aerobic cells. However, free heme is toxic. Therefore, cells must balance heme synthesis with its use. We previously demonstrated that the feline leukemia virus, subgroup C, receptor (FLVCR) exports cytoplasmic heme. Here, we show that FLVCR-null mice lack definitive erythropoiesis, have craniofacial and limb deformities resembling tho...

Skeletal mandibular hypoplasia (SMH), one of the common types of craniofacial deformities, seriously affects appearance, chewing, pronunciation, and breathing. Moreover, SMH is prone to inducing obstructive sleep apnea syndrome. We found that brain and muscle ARNT-like 1 (BMAL1), the core component of the molecular circadian oscillator, was significantly decreased in mandibles of juvenile SMH p...

BACKGROUND Trichorhinophalangeal syndrome type I (TRPS I) is a rare autosomal dominant disorder clinically characterized by sparse and slow-growing hair, pear-shaped nose, elongated philtrum, thin upper lip, and bone deformities, in particular, cone-shaped epiphyses of the phalanges. Very recently, the responsible gene TRPS1 has been cloned on human chromosome 8q24. OBSERVATION We describe a ...

With reference to an excellent article published in your esteemed journal recently regarding the use of cone beam computed tomography (CBCT) for the detection of external root resorption, I would like to add some vital information on the use of CBCT in craniofacial field in the present era. CBCT allows the creation in “real time” of im‐ ages not only in the axial plane but also 2‐dimensional im...

OBJECTIVE This study was designed to evaluate the effectiveness of helmet therapy (DOC band) in the correction of patients with moderate to severe posterior deformational plagiocephaly. DESIGN In this prospective study, the infants were evaluated using 18 anthropometric measurements. PATIENTS The charts of 248 patients seen between August 1, 1995, and July 31, 1999, were reviewed, and 125 m...