The study objectives were to determine (i) if pre-ovulatory luteinizing hormone (LH) surges, undetected in urine by two immunoradiometric assays (IRMA), were detectable by an ultrasensitive immunofluorometric assay (IFMA) and (ii) the influence of creatinine adjustment on the detection and timing of the urinary LH surges. Daily urine specimens were contributed by healthy 25-36 year old voluntee...

BACKGROUND/AIMS Excretion of urinary compounds in spot urine is often estimated relative to creatinine. For the growing number of liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays of urine-excreted molecules, a fast and accurate method for determination of creatinine is needed. METHODS A high-throughput flow injection tandem mass spectrometry method for exact quantitation of cr...

The main aim of the study was to prove the compensative effect of intestine for renal function. Rat kidney was impaired by intragastrically administrating adenine (400 mg per day for 5 days). Intestinal tract was harvested and equally divided into 20 segments except cecum. Kidneys were harvested and histologically examined with hematoxylin-eosin staining kits. Uric acid, urea (BUN), and creatin...

To assess the inherent potential for detecting mild to moderate reductions in glomerular filtration rate, this study determined the biological variability of serum cystatin C and creatinine in 12 healthy subjects. After accounting for analytical variation, interindividual variance accounted for 93% and intraindividual variance accounted for 7% of serum creatinine biological variation. As such, ...

AIMS To investigate whether current occupational exposure of coke oven workers to polycyclic aromatic hydrocarbons (PAHs) results in genotoxic effects measured in peripheral blood lymphocytes and whether these biomarkers are associated with the biomarkers of exposure. METHODS Blood and urine samples were collected immediately after a shift at the end of a working week from 50 coke oven worker...

Background: Urinary albumin excretion has been purported to be strongly linked cardiovascular events in hypertensive patients. The prevalence of microalbuminuria patients with essential hypertension and its relationship target organ damage was evaluated the present study, as correlation except not deliberated upon much past. Objectives: To evaluate between reduced creatinine clearance subclinic...

Huestis and Cone reported in [J. Anal. Toxicol. 22 (1998) 445] that serial monitoring of D-THC-COOH/creatinine ratios in paired urine specimens collected at least 24 h apart could differentiate new drug use from residual D-THC-COOH excretion following acute marijuana use in a controlled setting. The best accuracy (85.4%) for predicting new marijuana use was for a D-THC-COOH/creatinine ratio 0.5...

them to "make the most of the limited time left." Parents vividly remembered the doctor's response to their distress. The doctor's ability to accept and understand the parents' grief was important in establishing trust and shaping the future relationship. Feelings of anger, guilt, and sadness are well known to be part of the process of grieving, which may begin at the time of diagnosis when the...