Named entity recognition (NER) is a fundamental technique in natural language processing that provides preconditions for tasks, such as question reasoning, text matching, and semantic similarity. Compared to English, the challenge of Chinese NER lies noise impact caused by complex meanings, diverse structures, ambiguous boundaries itself. At same time, compared with specific domains, open-domai...

belongs to a family of related peptides that includes the Urocortins. Stress potently releases CRF not only from the hypothalamus but also from extrahypothalamic neu-rons (Tsigos and Chrousos, 2002). Two genes have been Stress can induce cravings and relapse in abstinent identified in mammals that encode CRF receptors, CRF-drug addicts. In this issue of Neuron, Ungless et al. R1 and CRF-R2 (Car...

The effect of the corticotropin-releasing factor (CRF) receptor antagonists astressin and D-Phe CRF(12-41) injected i.v. on CRF-induced delayed gastric emptying (GE) was investigated in conscious rats. Gastric transit was assessed by the recovery of methyl cellulose/phenol red solution 20 min after its intragastric administration. The 55% inhibition of GE induced by CRF (0.6 microgram i.v.) was...

Corticotropin-releasing factor (CRF)-like peptides mediate their effects via two receptor subtypes, CRF1 and CRF2; these receptors have functional implication in the motility of the stomach and colon in rats. We evaluated expression and functions of CRF1 and CRF2 receptors in the rat small intestine (i.e., duodenum and ileum). CRF(1-2)-like immunoreactivity (CRF(1-2)-LI) was localized in fibers...

Stress is a complex human experience and having both rewarding and aversive motivational properties. The adverse effects of stress are well documented, yet many of underlying mechanisms remain unclear and controversial. Here we report that the anxiogenic properties of stress are encoded by the endogenous opioid peptide dynorphin acting in the basolateral amygdala. Using pharmacological and gene...

Recent studies' have established the presence of a factor ("activator," Coagulase-reacting factor, or CRF) in plasma which is required for the coagulation of blood by staphylocoagulase. Maximum CRF activity resides in the globulin fractions of plasma, and separation from prothrombin is best achieved by repeated Seitz filtration.10 The filtration involves different rates of adsorption of prothro...

In chronic uremia (CRF), malnutrition is an important determinant of morbidity in adults and impaired growth in children. Causes of malnutrition include anorexia and abnormal protein and amino acid metabolism. To determine how different levels of dietary protein and CRF interact to influence growth and nutritional status, CRF and sham-operated, pair-fed control rats were fed isocaloric diets co...

Stress can reinstate cocaine seeking through an interaction between the stress hormone corticotropin releasing factor (CRF) and glutamate release onto dopamine neurons in the ventral tegmental area (VTA). To better understand the underlying causes, synaptic mechanisms were investigated in brain slices from rats. In control tissue, EPSCs displayed concentration-dependent, bimodal responses to CR...

BACKGROUND High levels of physical activity (PA) and cardiorespiratory fitness (CRF) are each associated with a favorable cardiovascular disease (CVD) risk profile. However, the relationship between CRF and obesity is still inconsistent across studies, and there has been no thorough exploration of the independent contribution of CRF to different CVD risk factors in Chinese women. This study inv...