An entire school year of 8-9 year old schoolchildren in Sheffield were surveyed using the core questions of the international study of asthma and allergies in childhood in order to assess the morbidity associated with diagnosed asthma. Of 5321 children surveyed, replies were obtained from 4539 (85.3%). A current diagnosis of asthma was reported in 466 (10.3%), and a further 6.4% reported sympto...

Evaluation of the effect of hydroalcoholic extracts of Cassia occidentalis in mast cell degradation induced by clonidine in Rats. The effect of oral administration of hydroalcoholic extract of Cassia occidentalis leaves on clonidine induced mast cell degradation has been studied and is compared with the effect of oral administration of Sodium cromoglycate as standard on rats. A clonidine result...

Disodium cromoglycate (I; DSCG) was introduced in 1968 for the treatment of bronchial asthma. Evidence concerning its principal effects and possible mode of action has been described at some length in the recent literature (Cox, 1971 ; Cox & Altoanyan, 1970). Crystals of the compound exhibit a remarkable reversible water absorption (Cox, Woodard & McCrone, 1971), the number of water molecules p...

This open-label, prospective, multicentre, 4-week trial was undertaken to assess the efficacy and tolerability of twice daily levocabastine eye drops (0.5 mg/ml), with sodium cromoglycate nasal spray for the relief of concurrent nasal symptoms if required, in a total of 233 children with seasonal allergic conjunctivitis. No correlation between efficacy, tolerability and age was found. Investiga...

Twenty-seven patients with vernal conjunctivitis who remained symptomatic following treatment with corticosteroid drops and/or Opticrom drops (sodium cromoglycate 2%, benzalkonium chloride 0.01%) were treated with aspirin. Aspirin produced marked improvement in all patients apart from three. The possible mechanism of the efficacy of aspirin in vernal conjunctivitis is discussed.

Vernal keratoconjunctivitis (VKC) is usually considered as an allergic eye disorder of type I, and in most therapeutic trials it has been shown to yield to topical treatment with sodium cromoglycate. This has been confirmed in the present study of VKC patients from Israel. However, some of the cases seemed not to benefit from this treatment. In a survey of IgE levels in VKC patients in Israel t...

AIMS To design a simple method for the detection of microbe-immune complexes exploiting the optical and elastic properties of a biocompatible liquid crystalline material. METHODS AND RESULTS Aqueous solution of disodium cromoglycate (DSCG), a lyotropic chromonic liquid crystal (LCLC), was aligned in a glass cell so as to be optically dark in polarized light. Immune complexes of at least three...

of treatment and also later, when the patient is apparently adequately treated according to the prothrombin ratio. It appears that patients with venous lesions require more anticoagulant to produce the same partial thromboplastin clottingtime than do patients with arterial lesions, and this may have a bearing on relapses and further thromboses. Examination of results from 21 patients when they ...

This study was undertaken to examine the possibility that IgE is not the only immunoglobulin responsible for immediate allergic reactions. A group of asthmatics were investigated in whom immediate allergic reactivity of the bronchi to common inhalant allergens had been confirmed by provocation tests. Their sera were fractionated and the reaginic activity of the immunoglobulin classes was studie...

The process of re-entrainment and re-dispersion of powder particles is studied both theoretically and experimentally in order to discuss the possibilities of improvement of the quality of aerosol emitted from dry powder inhalers (DPI). The eddy fluid particle model (EFPM) is employed to solve turbulent flow structure in the microscale in a channel with various types of turbulence promoters. The...