The management of trucks in a cross-docking platform is a process under five steps: the arrival, the control, the unloading, the transfer and finally the loading. In each of these steps, a sequence of decisions arise. To achieve an optimal and robust solutions, the interdependencies between the different planning functions should be taken into account, and scheduling decisions must be made simu...

Lead optimization benefits from including structural knowledge of the target. We present a new method that exploits quantitatively NMR amide proton chemical shift perturbations (CSP) on the protein side for protein-ligand docking. The approach is based on a hybrid scoring scheme consisting of a weighted sum of DrugScore, describing protein-ligand interactions, and Kendall's rank correlation coe...

Protein receptor rearrangements upon ligand binding are a major complicating factor in structure-based drug design. An accurate prediction of these so-called induced fit phenomena calls for ligand docking and virtual screening approaches capable of considering receptor flexibility. We present Fleksy [1], a flexible approach aimed at accurately positioning small molecule ligands into a protein r...

Cross docking is a logistics strategy that strives to reduce inventory holding costs, shipping costs, and delays in delivering the products. In this research, an optimization model is presented for split loading and unloading products by suppliers and customers, vehicle routing with fuzzy possibilistic time window constraints among them, assignment of vehicles to cross dock, consolidation and i...

Today, many companies after achieving improvements in manufacturing operations are focused on the improvement of distribution systems and have long been a strong tendency to optimize the distribution network in order to reduce logistics costs that the debate has become challenging. Improve the flow of materials, an activity considered essential to increase customer satisfaction. In this study, ...