Factor XIIIa crosslinks a limited number of substrates via epsilon(gamma-glutamyl)-lysyl bond formation. It crosslinks fibrin to itself, alpha 2-plasmin inhibitor and fibronectin to fibrin, and fibronectin to collagen. Results presented here show that plasma von Willebrand factor (vWF) is a substrate for factor XIIIa and can be crosslinked to fibrin during gel formation. vWF-fibrin crosslinking...

Scleroglucan is a natural polysaccharide, produced by fungi of the genus Sclerotium, that has been extensively studied for various commercial applications (secondary oil recovery, ceramic glazes, food, paints, etc.) and also shows several interesting pharmacological properties. This review focuses its attention on the use of scleroglucan, and some derivatives, in the field of pharmaceutics and ...

Nowadays, synthesis and application of Metal Nano-Clusters (MNC) attract great attention of scientists and technologists due to their unique electrical, magnetic and optical properties that differ from those of the bulk material. Nevertheless metallic nanoparticles are sometimes unstable and their stabilization is a crucial point to be solved in order to design new sensing devices which contain...

In vitro analysis of drug release and antimicrobial activity of the coblended crosslinked polymeric fibre device (PFD) were investigated. The fibre loaded with ciprofloxacin and diclofenac sodium was comprised of alginate and glycerol crosslinked with barium cations. The pH dependent drug release was evident with ciprofloxacin and diclofenac sodium diffusing from the fibre at pH 4.0 compared to...

Ballistic performance, at effective strain rates of (10–10 s ), for polymeric dicyclopentadiene (pDCPD) was compared with two epoxy resin/diamine systems with comparable glass transition temperatures. The high rate response was characterized in terms of a projectile penetration kinetic energy, KE50, which describes the projectile kinetic energy at a velocity with a 50% probability of sample pen...

The purple membrane ofHalobacterium halobium contains a single protein known as bacteriorhodopsin, which is composed of 1 mol retinal]mol bacterio-opsin [ 1 ]. The organization of the protein within each purple membrane sheet is that of an exact 2-dimensional crystal. X-ray and electron diffraction data have revealed that the bacteriorhodopsin in purple membrane is arranged as trimeric units in...

Coagulation factor V (FV) has been shown to be synthesized in both the liver and megakaryocytes. We now present evidence that FV can be covalently crosslinked by an enzyme originating from megakaryocytes to form polymeric multimers of factor V. The guinea pig megakaryocyte enzyme appears to be factor XIIIa since the FV-crosslinking activity (1) had an absolute requirement for Ca++, (2) was comp...

In this work matrix based nanoparticulate polymer systems have been designed using the diacrylate derivative of the well-known biocompatible polymer, poly(ethylene glycol) (PEG). This has been crosslinked using bifunctional (ethyleneglycol dimethacrylate) and tetrafunctional (pentaerythritol tetraacrylate) crosslinkers in varied concentrations (10-90%) to result in a polymeric network. The cros...

Stevia rebaudiana plant leaves were used for biosynthesis of gold nanoparticles (AuNPs). Transmission electron microscope images showed various shapes and sizes AuNPs. Various amounts AuNPs added to polyvinyl alcohol/carboxymethylcellulose (PVA/CMC, 40/60) via the casting method. The X-ray diffraction (XRD) spectrum pure blend shows amorphous nature blend. FTIR spectra interaction between PVA/C...