THE LONG-TERM results of transplantation against a true positive historic crossmatch due to IgG alloantibody are unclear. Tacrolimus is a novel immunosuppressive agent that has been found to be safe and effective in renal transplantation. l We report herein our long-term experience with 47 patients (mean age 41.8 :!: 14.3 years) who underwent cadaveric renal transplantation against a positive h...

Aims: In resource limited settings, cross matching procedures are usually limited to the conventional antiglobulin technique. Pre­ transfusion screening for red cell alloantibodies are not carried out routinely. The study was aimed at evaluating the usefulness of antibody screening as a surrogate to antiglobulin crossmatch procedure. Methods: A total 250 pregnant women attending the antenatal c...

There are many highly sensitized patients on the kidney waiting lists of organ exchange organizations because it is difficult to find a crossmatch negative cadaver kidney for these patients. Recently, several protocols have been developed to remove the donor-specific human leukocyte antigen (HLA) antibodies from the serum of these patients before transplantation. These approaches, including the...

We investigated the average operating time and extent of intra-operative blood loss in orthognathic surgeries performed using induced hypotensive general anaesthesia, with the intention of devising a practical guideline for blood unit preparation for these procedures. We prospectively studied 32 Chinese patients undergoing surgery to correct dentofacial deformities at a public hospital in Hong ...

The presence of donor-specific alloantibodies (DSAs) against the MICA antigen results in high risk for antibody-mediated rejection (AMR) of a transplanted kidney, especially in patients receiving a re-transplant. We describe the incidence of acute C4d+ AMR in a patient who had received a first kidney transplant with a zero HLA antigen mismatch. Retrospective analysis of post-transplant T and B ...

dictive value for subsequent compatibil¬ ity. In circumstances where the anti¬ body screen is positive, however, additional testing becomes necessary. The antibody expressed in the recipi¬ ent's serum must be characterized and the donor red blood cells tested for the presence of the corresponding antigen. The process of characterizing donor red blood cells as to their expression ofa particular ...

A Positive Pre-Transplant Endothelial Precursor Cell Crossmatch does not Imply Reduced Long-Term Kidney Graft Function Markus Gäbel1, Ayeda AlMahri2,3, Lennart Rydberg2, Jan Holgersson2, and Michael E. Breimer1* 1Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, Bruna stråket 5, S-413 45 Gothenburg, Sweden 2Department of Clinical Chemistry and Transfusion M...

A 52-year-old woman underwent bilateral lung transplantation for rheumatoid arthritis–associated interstitial lung disease. Her pretransplant course was notable for immunosuppressive therapy for rheumatoid arthritis with adalimumab, azathioprine, and prednisone. She exhibited extensive pretransplant allosensitization, including 3 low-intensity donorspecific antihuman leukocyte antigen antibodie...

Henze-Penrose divergence is a non-parametric divergence measure that can be used to estimate a bound on the Bayes error in a binary classification problem. In this paper, we show that a crossmatch statistic based on optimal weighted matching can be used to directly estimate Henze-Penrose divergence. Unlike an earlier approach based on the Friedman-Rafsky minimal spanning tree statistic, the pro...