Evolutionary approaches to molecular docking typically use a realvalue encoding with standard genetic operators. Mutation is usually based on Gaussian and Cauchy distributions whereas for crossover no special considerations are made. The choice of operators is important for an efficient algorithm for this problem. We investigate their effect by performing a locality, heritability and heuristic ...

Feasibly implemented Web-based smoking media literacy (SML) programs have been associated with improving SML skills among adolescents. However, prior evaluations have generally had weak experimental designs. We aimed to examine program efficacy using a more rigorous crossover design. Seventy-two ninth grade students completed a Web-based SML program based on health behavior theory and implement...

Testing the equivalence of treatments in a two-period crossover design setting occurs often in the pharmaceutical industry. These studies usually compare the rate and extent of absorption of two different drugs or two formulations of the same drug, where one is the accepted standard therapy. The commonly accepted rule for concluding bioequivalence requires the 90% confidence interval for the me...