Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms responsible for nervous system dysfunction are mainly related to the upregulation of the host immun...

BACKGROUND Mice overexpressing thymic stromal lymphopoietin (TSLP) develop mixed cryoglobulinemia with renal disease closely resembling human cryoglobulin-associated membranoproliferative glomerulonephritis (MPGN), including glomerular deposits of immunoglobulins and complement. We assessed the effect of complement inhibition through overexpression of Crry (complement receptor-1 related gene/pr...

Essential cryoglobulinaemia was detected in 44 out of 150 patients (29%) screened on the basis of histological confirmation of chronic inflammatory liver disease (chronic persistent or aggressive hepatitis, or cirrhosis). Cryoglobulinemia prevailed in the patients whose hepatic tissue showed more features of active inflammation; also, a female prevalence was observed. There were no correlations...

Case presentation: A 8-year-old girl, born in southeast Brazil, was taken to the neurologist by her parents investigate repeated unexplained neurological deficits. When she 4 years old, presented with livedo reticularis, abdominal pain, fever, and lower digestive hemorrhage. She extensively investigated, showing increased ESR RCP, negative tests for ANA, rheumatoid factor, ANCA, cryoglobulin, a...

Introduction. Several viruses including hepatitis C virus (HCV) and human immunodeficiency (HIV) can induce vasculitis. Aim. We aimed to study the incidence, risk factors, severity of skin vasculitis in patients with HCV HCV/HIV coinfection. Patients Methods. T he group included 331 (254 77 coinfection) referred a specialized hepatology center for antiviral therapy infection. Results. Skin was ...