نتایج جستجو برای: cryptococcal
تعداد نتایج: 2972 فیلتر نتایج به سال:
SETTING Inpatient medical wards, Department of Medicine, University Teaching Hospital, Lusaka, Zambia. OBJECTIVE To define the natural history, clinical presentation, and management outcome of microbiologically confirmed cryptococcal meningitis in adult AIDS patients treated under local conditions where antifungal and antiretroviral therapies are not routinely available. DESIGN A descriptiv...
BACKGROUND Cryptococcal meningitis (CM) constitutes a significant source of mortality in resource-limited regions. Cryptococcal antigen (CRAG) can be detected in the blood before onset of meningitis. We sought to determine the cost-effectiveness of implementing CRAG screening using the recently developed CRAG lateral flow assay in Uganda compared to current practice without screening. METHODS...
BACKGROUND Cryptococcal meningitis is a major cause of HIV/AIDS-related deaths in Africa. Cryptococcosis is a neglected killer. However, meningitis can be prevented by early cryptococcal antigen (CrAg) screening and preemptive antifungal treatment during a prolonged period of detectable, subclinical infection. We determined the prevalence of cryptococcal antigenemia in comparison to CD4 count a...
BACKGROUND Globally, Latin America ranks third among regions with most cases of AIDS related cryptococcal meningitis. In 2009, a lateral flow immunoassay (LFA) for the detection of cryptococcal antigen (CrAg) was developed as a potential point-of-care test for diagnosis of cryptococcal infection. In 2011 World Health Organizations recommended on CrAg screening for HIV positive persons with CD4 ...
The mechanism of host cell recognition of Cryptococcus neoformans, an opportunistic fungal pathogen in immunocompromised patients, remains poorly understood. In the present study, we asked whether the DNA of this yeast activates mouse bone marrow-derived myeloid dendritic cells (BM-DCs). BM-DCs released IL-12p40 and expressed CD40 upon stimulation with cryptococcal DNA, and the response was abo...
Infection of the central nervous system by Cryptococcus neoformans has been reported in the medical literature often enough to be now widely recognized as one of the causes of chronic meningitis. The symptoms and signs emphasized include headache, vomiting, papilloedema, progressive blindness, hemiplegia, and alterations of mental status. Cryptococcal meningitis is commonly associated with pre-...
Background. Mortality for cryptococcal meningitis remains significant, in spite of available treatment. Resistance to first-line maintenance therapy, particularly fluconazole, has been reported. Methods. A retrospective chart review was performed on immunocompromised patients with cryptococcal meningitis, who had susceptibility testing performed between January 2001 and December 2011, at 3 ho...
a case of cryptococcal meningitis is reported in a 26 year old man by the medical mycology department of the school of public health, tehran university. the patient with the symptom of meningitis was admitted to the hospital with the symptom of meningitis was admitted to the hospital. lumbar puncture was performed in the hospital. after direct examination and culture of cerebrospinal fluid, cry...
Cryptococcal meningitis is a disease that afflicts approximately 1 million human immunodeficiency virus (HIV)–infected individuals annually, with >600 000 deaths, predominantly in the developing world, where antiretroviral therapy is less available [1]. Therapy of cryptococcal meningitis has been poorly effective in resource-limited settings, where 10-week mortality rates have averaged 25%–30%,...
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