نتایج جستجو برای: ctla4
تعداد نتایج: 1760 فیلتر نتایج به سال:
Bone marrow-derived dendritic cells (DCs) can be genetically engineered using adenoviral (Ad) vectors to express immunosuppressive molecules that promote T cell unresponsiveness. The success of these DCs for therapy of allograft rejection has been limited in part by the potential of the adenovirus to promote DC maturation and the inherent ability of the DC to undergo maturation following in viv...
In the past decade, a number of case-control studies have been carried out to investigate the relationship between the CTLA4 gene polymorphisms and type 1 diabetes (T1D). However, these studies have yielded contradictory results. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the relationship between the CTLA4 polymorphism and T1D. In total...
We discuss two novel QCD effects which enhance the production of heavy quarks and supersymmetric hadrons beyond that conventionally expected from gluon fusion. Invited talk presented at the 12th SLAC Summer Institute on Particle Physics Stanford, California, July 23 August 3, 1984 * Work supported by the Department of Energy, contract DE AC03 76SF00515.
We investigated a patient who developed multiple sclerosis (MS) during treatment with the CTLA4-blocking antibody ipilimumab for metastatic melanoma. Initially he showed subclinical magnetic resonance imaging (MRI) changes (radiologically isolated syndrome). Two courses of ipilimumab were each followed by a clinical episode of MS, 1 of which was accompanied by a massive increase of MRI activity...
Objectives This multicentre retrospective study in Japan aimed to assess the retention of biological disease-modifying antirheumatic drugs and Janus kinase inhibitors (JAKi), clarify factors affecting their a real-world cohort patients with rheumatoid arthritis. Methods The included 6666 treatment courses (bDMARD-naïve or JAKi-naïve cases, 55.4%; tumour necrosis factor (TNFi) = 3577; anti-inter...
Abstract We recently demonstrated, in a mouse heart transplant model, the therapeutic effect of Enhanced Costimulation Blockade: transient combination CTLA4-Ig with JAK inhibitor Tofacitinib (Tofa). In same we also proved efficacy graft-localized delivery by means Tofa releasing hydrogel (Tofa-Hydro). this study, implemented orthotopic hind-limb VCA model to delineate any differential drug requ...
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