BED model (Biological Effective Dose) for Head and Neck tumors Hyperfractionation TPO was optimizedwith Pareto-Multiobjective (PMO) Genetic Algorithms (GA) software. Artificial Intelligence (AI) with GA is applied on Radiotherapy Treatment Planning Optimization (TPO). Secondly, the review of NEffective (Effective Tumor Population Clonogens Number) optimization breast cancer clonogens parameters...

The orange title compound, C(19)H(17)N(3)O(4)S, can be synthesized either via microwave-mediated combinatorial chemistry strategies or conventional synthetic procedures. The phenyl and meta-nitrophenyl C(6) rings are essentially coplanar with the central imidazolyl ring, with interplanar angles of 0.87 (5) and 0.97 (4), respectively, resulting in optimum conjugation (SCH(2) moiety included); la...

Postmenopausal osteoporosis (PMO) increases bone fragility and the risk of fractures, and impairs the healing procedure of bone defects in aged women. The stromal cell‑derived factor-1α (SDF-1α)/CXC chemokine receptor type 4 (CXCR4) axis helps to maintain the biological and physiological functions of bone marrow mesenchymal stem cells (BMSCs) and increase the homing efficiency of BMSCs. The pre...

Growth in the number of PMOs established by the industry over last decade and ever growing body of literature on PMO related research in academia is a clear indication that there is very clear interest of researchers, practitioners and industries across the globe to understand and explore value propositions of PMO. However, there is still a lack of consensus on many critical aspects of PMOs. Wh...

The factors that may modulate ventilatory muscle fatigue during exercise are controversial. In this study the contribution of acidosis to exercise-induced diaphragmatic fatigue was investigated, using measurements of the twitch mouth pressure response (tw,Pmo) to cervical magnetic stimulation. After learning sessions, 14 healthy subjects performed two cycling tests (at 60% of maximal aerobic po...

Latar Belakang: Tuberkulosis merupakan penyakit penyebab kematian kedua pada anak. Salah satu tatalaksana Tuberculosis anak yaitu dengan pemberian Obat Anti (OAT). Tujuan: Untuk mengetahui hubungan peran orangtua sebagai pengawas minum obat (PMO) kepatuhan tuberculosis di Poli DOTS RSUD Kota Bogor tahun 2022 Metode: Desain penelitian ini menggunakan pendekatan cross-sectional jumlah populasi 50...

The topological diversity of lithium-boron imidazolates LiB(imid)(4) was studied by combining topological enumeration and ab initio DFT calculations. The structures based on zeolitic rho, gme and fau nets are shown to be stable and have high total hydrogen uptake (6.9-7.8 wt.%) comparable with that of MOF-177.

Abstract Background Postmenopausal osteoporosis (PMO) that results from estrogen withdrawal is the most common primary among older women. However, little known about mechanism of PMO, and effective treatment PMO limited. Methods We used real-time polymerase chain reaction (qPCR), Western blotting, RNA pull down to investigate relationship between miR-186 MOB Kinase Activator 1A (Mob1). Also, we...

BACKGROUND Due to the impending depletion of fossil fuels, it has become important to identify alternative energy sources. The biofuel industry has proven to be a promising alternative. However, owing to the complex nature of plant biomass, hence the degradation, biofuel production remains a challenge. The copper-dependent Auxiliary Activity family 9 (AA9) proteins have been found to act synerg...

OBJECTIVES Emerging evidence implicates the SNAIL family of transcriptional repressors in cancer development; however, the role of SNAIL in colorectal cancer has not been established. To investigate the importance of SNAIL in colorectal carcinogenesis, we examined the phenotypic and cellular consequences of SNAIL down-regulation in the MIN mouse. METHODS Twenty-eight male MIN mice were random...