Addition of skin penetration enhancer in the formulation is the simplest and most common technique to improve transdermal permeation. However chemical penetration enhancers are known to cause skin irritation. In this research project we are proposing natural penetration enhancer (olive oil) based nano-emulsion. The aim of the present study was to investigate the olive oil based nano-emusion for...

Recently we proposed a periodic surface model to assist geometric construction in computer-aided nano-design. This implicit surface model helps create super-porous nano structures parametrically and support crystal packing. In this paper, we study construction methods of Minkowski sums for periodic surfaces. A numerical approximation approach based on the Chebyshev polynomials is developed and ...

The objective of present work was development of felodipine nano emulsion formulations using sesame oil as sole lipid phase by high pressure homogenization technique. A combination of non-ionic surfactants was used based on HLB (Hydrophilic lipophilic balance) values. The resultant nano emulsions were characterized for particle size, zeta potential. The particle size for the optimized nano emul...

Turmeric, an essential ingredient of culinary preparations of Southeast Asia, contains a major polyphenolic compound, named curcumin or diferuloylmethane, which eliminates cancer cells derived from a variety of peripheral tissues. Although in vitro experiments have addressed its anti-tumor property, no in vivo studies have explored its anti-cancer activity in the brain. Oral delivery of this fo...

BACKGROUND The objective of this study was to prepare, characterize, and evaluate a folate-modified self-microemulsifying drug delivery system (FSMEDDS) with the aim to improve the solubility of curcumin and its delivery to the colon, facilitating endocytosis of FSMEDDS mediated by folate receptors on colon cancer cells. METHODS Ternary phase diagrams were constructed in order to obtain the m...

Stable oil-in-water nanoemulsions were generated by ultra-high-pressure homogenization (UHPH) at 140 and 210 MPa for use as nano-vesicular vehicles (NVV) to carry hydrophobic generally recognized safe (GRAS) curcumin (CU) whey protein isolate (WPI) in aqueous nutraceutical systems. Curcumin was used its antioxidant activity participation the Michael reaction with nucleophiles pHs above 8.0. Two...

Eye is a critical part of the body that readily available and with damage having direct effects on life an individual. Delivery ocular drugs always remain challenging for healthcare professionals scientists all over world due to challenges dynamic opthalamic environment provides. These involves different barriers like corneal epithelium, stroma, sclera other bio-membranes (static barriers), cho...

474 Cancer Biology & Therapy Volume 11 Issue 5 Commentary to: Lim KJ, Bisht S, Bar EE, Maitra A, Eberhart CG. A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol Ther 2011; This issue.

Gram-positive bacteria cause various diseases from the superficial skin to deep tissue infections. The capability of causing numerous is due production virulence factors which are tightly regulated by genes. Various pathogenic e.g. Staphylococcus, Mycobacterium, and Listeria capable lethal infections in humans animals. Conventional antibiotics, targeted combinatorial drugs used as therapeutic a...

Curcumin is a widely used Indian rhizomatous medicinal plant from the family Zingiberaceae, an orange-yellow polyphenolic and hydrophobic phytochemical element of turmeric herb (Curcuma longa Linn.), has been shown to have strong immunomodulatory properties varieties nutritional value in both animals humans. Science technology, relatively recent scientific research field, commonly medical scien...