Human T lymphotropic virus-I (HTLV-I)-specific T cell lines were established and cloned. K5, an OKT8+ clone bearing multiple proviral integration sites, retained its HTLV-I-specific cytotoxicity and a normal dependence on interleukin 2 (IL-2), indicating that there is a finite number of transforming integration sites. R2, an OKT4+ HTLV-I-infected clone, initially mounted a proliferative respons...

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive type of non-Hodgkin's lymphoma that can be primary the skin or secondary, caused by Human lymphotropic virus (HTLV-1) infection. The prevalence HTLV-1 infection high in Brazil, however reports ATLL are rare, possibly underdiagnosed and underreported. This paper presents a case report patient coming from south region country with few cited c...

This review focuses on current approaches to understanding the immunopathogenesis of human T cell lymphotropic virus (HTLV) type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) based on newly developed molecular and immunologic techniques that have been adapted to studies of HTLV-I proviral load, HTLV-I mRNA, and HTLV-I tax-specific CD8 T cells. These methods enable researchers t...