A 16-month-old male patient with cyclic neutropenia was found to have cyclic fluctuations of monocytes, lymphocytes, platelets, and eosinophils in the peripheral blood. Changes in lymphocyte counts were not obviously related to B, T, or natural killer cells. All classes of immunoglobulins were elevated throughout the cycle. Studies of the marrow morphology revealed remarkable cyclic oscillation...

Anti-Müllerian hormone (AMH) has been observed to decrease with the development of hemorrhagic anovulatory follicles (HAFs) in mares. Two studies were conducted to evaluate AMH concentration in mares with HAFs compared to seasonally anoestrous and cyclic mares, and to elucidate changes of AMH with the development of luteinised unruptured follicles (LUFs). In study 1, AMH and progesterone were e...

Administration of human chorionic gonadotropin (hCG) to male rats was followed by dose-related changes in luteinizing hormone (LH) receptors in the testis. After treatment with a low dose of hCG (10international units), the number of LH receptors increased slightly over the first 24 hr, then fell to about 30% of the control value. These changes occurred with occupancy of only 8% of the availabl...

OBJECTIVE We developed a novel method using anatomic markers along the thoracic aorta to accurately quantify longitudinal and circumferential cyclic strain in nondiseased thoracic aortas during the cardiac cycle and to compute age-related changes of the human thoracic aorta. METHODS Changes in thoracic aorta cyclic strains were quantified using cardiac-gated computed tomography image data of ...

this paper presents the results of a series of monotonic and post-cyclic triaxial tests carried out on a clay specimen and three types of clay-sand mixed specimens. the focus of the paper is on the post-cyclic mechanical behavior of the mixed specimens, as compared to their monotonic behavior. analyses of the tests results show that cyclic loading degrade undrained shear strength and deformatio...

Microwave irradiation has become an acceptable technique for assessing small quantities of neurochemical substances in the brain. These substances are acetylcholine, cyclic nucleotides, biogenic amines, enkephaline and r-aminobutylic acid (1-4). Rapid inactivation of brain enzymes by microwave irradiation prevents postmortem changes of tissue substances. Although it is known that brain biogenic...

our studi es have shown normal cyclical patterns of ovarian stero ids and pituitary gonadotropines in pa tients with congenital absccncc o f th e uteru s. it appears that the life-long abscence of a fun ctioning uterus has no effect o n the fun ctional life span o f t he co rpus lurer um, but may have some effect in the level o f estrogenes iu th e seco nd half of the cycle.

Glycogen autophagy in newborn rat hepatocytes was studied by using enzyme determinations and electron microscopy. Cyclic AMP induced glycogen autophagy in these cells. Glycogen-hydrolyzing acid glucosidase activity increased whereas acid mannose 6-phosphatase activity decreased in the liver of these animals. Parenteral glucose, which prevents postnatal glucagon secretion and tissue cyclic AMP e...

Basal levels of cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate were determined in mouse epidermis in vivo after a single topical treatment with the tumor promoter phorbol myristate acetate. No changes in cyclic adenosine 3':5'-monophosphate levels were found from 0 to 72 hr after treatment. A twofold increase in cyclic guanosine 3':5'-monophosphate was found 36 hr...

The cyclic nucleotides, cyclic AMP and cyclic GMP, like intracellular calcium, are involved in a vast array of intracellular signaling processes. But knowledge of the cellular and subcellular concentrations of cAMP and cGMP, and of the kinetics and spatial distributions of the changes of their concentration in situ, have lagged far behind our knowledge of the corresponding features of calcium s...