A platform technology has been developed and tested for delivery of intracellular-acting peptides through electrostatically complexed nanoparticles, or nano-polyplexes, formulated from an anionic endosomolytic polymer and cationic therapeutic peptides. This delivery platform has been initially tested and optimized for delivery of two unique vasoactive peptides, a phosphomimetic of heat shock pr...

The influence of through-bond interactions on nonadiabatic excited-state dynamics is investigated by time-resolved photoelectron spectroscopy (TRPES) and ab initio computation. We compare the dynamics of cyclohexa-1,4-diene, which exhibits a through-bond interaction known as homoconjugation (the electronic correlation between nonconjugated double bonds), with the nonconjugated cyclohexene. Each...

Several self-assembling peptide and protein systems that form nanotubes, helical ribbons and fibrous scaffolds have recently emerged as biological materials. Peptides and proteins have also been selected to bind metals, semiconductors and ions, inspiring the design of new materials for a wide range of applications in nano-biotechnology.

Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophag...

We functionalized peptide nanofibers to provide a nano-scale template for the display of biomolecules and inorganic nanoparticles using metal ion coordination. Nanofibers assembled only in the presence of certain divalent metal ions, and could be readily dissolved by a metal-chelating reagent, EDTA.

Here we report a peptide directed synthesis of co-shell nanocables by sequential guide formation of silica insulating shells on metallic gold nanoribbons which is significant since it demonstrated the ability to fabricate a functional nano-electronic component using a biomimetic method.

background: prostate cancer after lung cancer is the second cause of cancer-associated death in men. in recent years, targeted therapy of cancer has attracted researchers attention. the targeted therapy lead to decrease in side effects of drugs. studies have indicated that targeting peptides for cancer cells represent valuable tools for diagnostic and therapeutic. recently, phage display peptid...

Safe- and convenient-to-handle surrogates of hazardous chemicals are always in demand. Recently introduced cyclohexa-1,4-dienes with adequate substitution fulfil this role as El+/H- equivalents in B(C6F5)3-catalysed transfer reactions of El-H to π- and σ-donors (C 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 000000000000000000000000000...

In this study, a series of 4-(3-benzylbenzo[ d]thiazol-2(3 H)-ylidene)-cyclohexa-2,5-dien-1-one derivatives are efficiently synthesized in excellent yields by reactions 2-chlorobenzothiazole, benzyl bromides, and phenols acetonitrile under reflux catalyst-free conditions the presence triethylamine for 2 h. The structures products characterized NMR, IR, EI-MS, elemental analyses.