The authors administered procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU, lomustine), and vincristine (PCV) to 86 patients with recurrent glioblastoma. There were three partial responses, but no complete responses. Median progression-free survival was 17.1 weeks and progression-free survival at 6 months was 38.4%. World Health Organization grade III/IV hematologic toxicity was ...

well as their derivatives have not been widely applied as therapeutics so far, although they exhibit significant biological activities e.g. antibacterial [1], antituberculitic [2, 3], antitumorus [4], antibacillary [5]. Amidrazones are also used for the synthesis of heterocyclic systems, 1,2,4ñtriazole derivatives [6, 7, 8]. Moreover the compounds, containing cyclic substituents (cyclopropyl, c...

A flexible organic sheet spontaneously assembled under mild conditions from a tri-carbamate. By introducing cyclohexyl side chains as 'pillars' between the sheets, a hydrogen bonded organic framework was formed which displayed a capacity for accommodating and releasing guest molecules. The guest size/shape selectivity of the lamellar framework was demonstrated by testing with various guests.

One of the ways to ensure high reliability detection, identification and accuracy quantitative determination toxic chemicals (TC) in environmental biomedical samples by gas liquid chromatography-mass spectrometry methods is use internal standards (IS) as additives analyzed sample, which, contrast from target TC, contain stable isotopes such D, 13 C, 15 N, 18 O. In this case, preference given mo...

The DNA sequenceselectivitiesof guanine-N7alkylation producedby three chloroethylating antitumor agents, I-(2-chloroethyl)-3-(cis-2-hy droxy)cyclohexyl-l-nitrosourea(cis-2-OH CCNU), 2-chloroethyl(meth ylsulfonyl)methanesulfonate,and 8-carhamoyl-3-(2-chloroethyl)imidazo 15,l-dl-l,2,3,5-tetrazin-4(3H)-one (mitozolomide), were examined using a modification of the Maxam and Gilbert sequencing techn...

Compound 1 [(E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1S,4S)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide], a new, potent, selective anaplastic lymphoma kinase (ALK) inhibitor with potential application for the treatment of cancer, was selected as candidate to advance into efficacy studies in mice. However, the compound underwent mou...