Vascular stenosis mainly on the basis of arteriosclerotic disease represents one of the major problems in cardiovascular disease. Vascular stenosis contributes significantly to the clinical consequences of arteriosclerotic disease being the leading cause of death in western countries. The etiology of vascular disease is very complex and many factors have been implicated such as abnormalities of...

ITE JOURNAL / SEPTEMBER 2003 RAIL FREIGHT TRANSPORT IN EUROPE—TIME FOR A CHANGE While transport in Europe has grown at an annual rate of 2.5 to 3 percent over the last 20 years, rail transport has experienced a significant decline. This process may be appreciated by comparing figures from 1970 and 1999: In 1970, railway market share in the European Union (EU) was registered at 21 percent. By 19...

The posterior cingulate cortex is a highly connected and metabolically active brain region. Recent studies suggest it has an important cognitive role, although there is no consensus about what this is. The region is typically discussed as having a unitary function because of a common pattern of relative deactivation observed during attentionally demanding tasks. One influential hypothesis is th...

Cell contractility and migration by integrins depends on precise regulation of protein tyrosine kinase and Rho-family GTPase activities in specific spatiotemporal patterns. Here we show that protein tyrosine phosphatase PTP1B cooperates with β3 integrin to activate the Src/FAK signalling pathway which represses RhoAmyosin-dependent contractility. Using PTP1B null (KO) cells and PTP1B reconstitu...

The notion of distance is fundamental to many aspects of computational geometry. A classic approach to characterize the distance properties of planar (and highdimensional) point sets that has been studied since the early 1980s are proximity graphs (Section 32.1). Proximity graphs are geometric graphs in which two vertices p, q are connected by an edge (p, q) if and only if a certain exclusion r...

Certain naturally occurring spaces have isomorphic v 1-periodic homotopy groups. To each is associated a mapping telescope whose ordinary homotopy groups equal the v 1-periodic homotopy groups of the space. It is proved that the mapping telescopes of the spaces are homotopy equivalent .

Acetaminophen is a leading cause of acute liver failure (ALF). Genetic differences might predispose some individuals to develop ALF. In this exploratory study, we evaluated genotype frequency differences among patients enrolled by the ALF Study Group who had developed ALF either intentionally from a singletime-point overdose of acetaminophen (n = 78), unintentionally after chronic high doses of...

Acetaminophen is a leading cause of acute liver failure (ALF). Genetic differences might predispose some individuals to develop ALF. In this exploratory study, we evaluated genotype frequency differences among patients enrolled by the ALF Study Group who had developed ALF either intentionally from a singletime-point overdose of acetaminophen (n = 78), unintentionally after chronic high doses of...