Two simple, rapid and inexpensive methods based on spectrophotometry and turbidimetry have been developed for the determination of cyproheptadine hydrochloride (CPH) in pure form and in dosage forms with Bromophenol Blue (BPB) as the reagent. The spectrophotometric method is based on the formation of an ion-pair complex between the drug and BPB in an acidic buffer. The ion-pair complex formed, ...

Objective: Losing weight in consequence of appetite loss can be a sign of a serious underlying condition. Currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. However, the clinical use of cyproheptadine hydrochloride is limited by its side effects. In Iranian traditional medicine, Coriandrum sativum stimulates the appetite. Therefore, the effect of Cori...

OBJECTIVE To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals. METHODS In the first step, Swiss albino female mice weighing 25-35 g were used. Eight groups each containing 8 mice were established as follows:- Control (saline), mirtazapine 5 mg/kg, 10 mg/kg, and 20 mg/kg, mirtazapine 10mg/kg and its combinations L-Nitro-L-Arginine ...

Nose nets, face masks, and magnesium supplementation were the most efficacious nonmedical therapies for treatment of headshaking. Of the pharmacological treatments, cyproheptadine, corticosteroids, and melatonin resulted in greatest improvement. Each of these treatments resulted in improvement in approximately 50% of headshaking horses. Authors’ addresses: Department of Veterinary Medicine and ...

The bilateral hemispheric ischemia in rats was induced by the occlusion of bilateral common carotid arteries after permanent electrocauterization of bilateral vertebral arteries at the level of the second cervical vertebra. In ischemic rats, (a) electroencephalograms became flat immediately after occlusion of carotid arteries, and (b) mortalities reached maximum levels at day 3 after recirculat...