Two simple, rapid and inexpensive methods based on spectrophotometry and turbidimetry have been developed for the determination of cyproheptadine hydrochloride (CPH) in pure form and in dosage forms with Bromophenol Blue (BPB) as the reagent. The spectrophotometric method is based on the formation of an ion-pair complex between the drug and BPB in an acidic buffer. The ion-pair complex formed, ...

Objective: Losing weight in consequence of appetite loss can be a sign of a serious underlying condition. Currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. However, the clinical use of cyproheptadine hydrochloride is limited by its side effects. In Iranian traditional medicine, Coriandrum sativum stimulates the appetite. Therefore, the effect of Cori...

Caffeine is consumed by over 80% of U.S. adults. This review examines the effects caffeine has on cognitive and physical function, since most real-world activities require complex decision making, motor processing and movement. Caffeine exerts its effects by blocking adenosine receptors. Following low (∼40mg or ∼0.5mgkg-1) to moderate (∼300mg or 4mgkg-1) caffeine doses, alertness, vigilance, at...

OBJECTIVE To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals. METHODS In the first step, Swiss albino female mice weighing 25-35 g were used. Eight groups each containing 8 mice were established as follows:- Control (saline), mirtazapine 5 mg/kg, 10 mg/kg, and 20 mg/kg, mirtazapine 10mg/kg and its combinations L-Nitro-L-Arginine ...

Nose nets, face masks, and magnesium supplementation were the most efficacious nonmedical therapies for treatment of headshaking. Of the pharmacological treatments, cyproheptadine, corticosteroids, and melatonin resulted in greatest improvement. Each of these treatments resulted in improvement in approximately 50% of headshaking horses. Authors’ addresses: Department of Veterinary Medicine and ...