Angiogenesis, the process of new vessel formation from the pre-existing blood vasculature, is critical for continuous tumor growth and is considered to be a validated antitumor target. The results of our previous study demonstrate the anti-angiogenic potential of an extract of Gleditsia sinensis thorns, which has been traditionally used in Korean medicine to remedy diverse diseases, including t...

The microfilament inhibitor cytochalasin D inhibits extrusion of the first polar body when present during the first meiotic division of mouse oocytes; however, it does not interfere with anaphase movement of chromosomes, and thus induces the formation of tetraploid oocytes. After the separation of chromosomes in anaphase, two spindles start to assemble. However, they merge rapidly and a single ...

This agent ( 2 ‘,,‘/mi) disrupts microfilaments in many cell types including the AM.2 It does not impair microtubular morphology. Quantitative bacteriologic methods demonstrate diminished uptake of live Staphylococcus aureus from shaking bacteriaAM suspensions in the presence of cytochalasin B. These effects are associated with striking diminution of ‘4C02 production from ‘4C-1-glucose and ‘4C-...

The cytoskeleton is critical to the viral life cycle. Agents like cytochalasin inhibit viral infections but cannot be used for antiviral therapy because of their toxicity. We report the efficacy, safety, and mechanisms by which gene delivery of human wild-type low-molecular-weight caldesmon (l-CaD) protects cell membrane integrity from adenovirus infection in a DF-1 cell line, an immortalized a...

Adrenocorticotropin (ACTH)-stimulated cholesterol transport to mitochondria has been quantitated in rat adrenals in vivo and in adrenal cell suspensions. The initial rate of transport (1.25 pg/mg of mitochondria/ min) is similar in vivo and in cell suspensions, but the mitochondrial cholesterol level reaches higher levels in uivo. ACTH stimulation of cholesterol transport into mitochondria when...

background: gemcitabine (2′, 2′-difluoro-2′- deoxycytidine, an analogue of deoxycytidine) is a relatively new drug with wide range of anti-cancer activity. in this study, radiosensitizing effects of gemcitabine was investigated on hela and mrc5 human originated cell lines under both chronically hypoxic and normoxic conditions using the micronucleus (mn) assay. materials and methods: for inducti...