نتایج جستجو برای: cytotoxic effect
تعداد نتایج: 1685829 فیلتر نتایج به سال:
We previously reported that MSTO-211H cells have a higher capacity to regulate Nrf2 activation in response to changes in the cellular redox environment. To further characterize its biological significance, the response of Nrf2, a transcription factor that regulates ARE-containing genes, on the synergistic cytotoxic effect of clofarabine and resveratrol was investigated in mesothelioma cells. Th...
Effect of metacycloprodigiosin, an inhibitor of killer T cells on murine skin and heart transplants.
Metacycloprodigiosin is an antibiotic that has been shown to suppress T-cell proliferation induced by concanavalin A in vitro. We examined the effect of metacycloprodigiosin on murine allogenic skin and heart transplantation models, and compared graft rejection with donor-specific cytotoxic T-cells and antibody activity. The antibiotic slightly prolonged the survival of C57Bl/6 heart and skin g...
In this paper, the authors identify the strategies that resistant subpopulations of cancer cells undertake to overcome the effect of the anticancer drug Topotecan. For the analyses of cell lineage data encoded from timelapse microscopy, data mining tools are chosen that generate interpretable models of the data, addressing their statistical significance. By interpreting the short-term and long-...
Several short linear peptides derived from cyclic bovine lactoferricin were synthesized and tested for their cytotoxic effect against the oral cavity squamous-cell carcinoma (OSCC) cell lines CAL27 and SCC15. As a control, an immortalized and nontumorigenic cell line, Het-1A, was used. Linear peptides based on the RRWQWR core sequence showed a moderate cytotoxic effect and specificity towards t...
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