Delta-toxin produced by Clostridium perfringens types B and C is a β-pore-forming cytotoxin. Here, using site-directed mutagenesis, we identified the amino acid residues that contribute to delta-toxin oligomerization binding. We replaced Lys-43 Ser-109 located in β-sandwich domain Arg-200 rim domain. Substitution of alanine for caused reductions both cytotoxicity oligomerization. However, excha...

introduction and aims: omeprazole is a gastric parietal cells proton pump inhibitor that is also active against h. pylori in vitro. this study was designed to examine the neutralization of h. pylori cytotoxicity on vero cells by omeprazole micronized in strains isolated from gastritis, ulcer, cancer and barrett's ulcer, to determine whether omeprazole can inhibit vacuolation of the vero cells i...