nitro-containing heteroaromatic derivatives structurally related to nitroimidazole (metronidazole) are being extensively evaluated against helicobacter pylori isolates. on the other hand, 1,3,4-thiadiazole derivatives have also demonstrated promising antibacterial potential. in present study, we evaluated anti-h. pylori activity of novel hybrid molecules bearing nitroaryl and 1,3,4-thiadiazole ...

an extremely facile and efficient procedure which has been developed for the synthesis of dihydropyrrol-2-ones. one-pot four-component reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of n,n,n,n-tetramethylguanidinium acetate [tmg][ac] in methanol at ambient temperature provides substituted dihydropyrrol-2-ones in good to high yields. the important aspects of...

background & aim: eucalyptus l'her. [an aromatic genera of the family (myrtaceae)] is native to australia and other tropical species is planted worldwide. the purpose of this study is to extract and identify the essential oils components of four species of eucalyptus l'her. cultivated in botanical garden of kashan, central iran. experimental: leaves of e. largiflorens, e. intertexta, ...

honey and royal jelly are complex heterogeneous mixtures of flower s’ nectar sugars proteins and bees’ glandular secretions. royal jelly is the hypo-pharyngeal gland excretion of the young worker honeybees (apis mellifera). the wonderful effects of royal jelly on the sexual ability and maturity of the queen has been an interesting topic and controversial issue for researchers for many years. th...

the uptake and transport of 9-nitrocamptothecin (9-nc), a potent anticancer agent, across caco-2 cell monolayers was studied as a free and plga nanoparticle loaded drug. different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. the transport of nanoparticles across the caco-2 cell monolayer as a func...

3,4-ِdihydropyrano[c]chromene derivatives were synthesized using sulfonic acid functionalized silica (sio2-pr-so3h) as a highly efficient heterogenous solid acid catalyst via one-pot three-component condensation of aromatic aldehydes with malononitrile and 4-hydroxycoumarin in excellent yields.

antioxidants are vital substances which possess the ability to protect the body from damage caused by free radical-induced oxidative stress. a variety of free radical scavenging antioxidants exist within the body which many of them are derived from dietary sources like fruits, vegetables and teas. this article describes a test method for screening the antioxidant activity of 60 iranian plants o...

introduction during the process photodynamic therapy (pdt), bleaching of photosensitizer induced by irradiation and generation of reactive oxygen species (ros) can provide some information concerning the efficiency of treatment. since gold nanoparticles (gnps) have been highlighted as efficient drug delivery systems, in this study, by utilizing gnps conjugated with 5 aminolevulinic acid (5-ala-...

introduction and aims: the northeastern region of iran has some of the highest rates of esophageal squamous cell carcinoma (escc) in the world. materials and methods: to investigate the role of polycyclic aromatic hydrocarbons (pahs) in the etiology of escc in northeastern iran, we measured urine 1-hydroxypyrene glucuronide (1-ohpg), a stable pah metabolite, in 99 inhabitants of this area. resu...