An optimized formulation of capsules containing Lansoprazole enteric-coated pellets using D-Optimal design with a polynomial statistical model were prepared by using Eudragit®L100 as an enteric coated polymer to provide resistance to simulated gastric acid dissolution in buffer media. D-Optimal experimental design was used to determine the optimal level for three coating layers that were applie...

We study the optimal design of absorption barriers and sample size for a simple random walk. High barriers yield more informative experiments, but may be more costly. We obtain optimal designs that are balancing the relative advantages of choosing a high barrier with few replications versus a lower barrier with more replications. We address the problem from a Bayesian, decision theoretic, viewp...

The main objective of the present study was to apply QbD methodology in the development of once-a-day sustained release quetiapine tablets. The quality target product profile (QTPP) was defined after the pharmaceutical properties and kinetic release of the innovator product, Seroquel XR 200 mg. For the D-optimal experimental design, the level and ratio of matrix forming agents and the type of e...

It is well-known that entrainment of particles into the froth is a key factor in the selectivity and performance of the flotation process, especially for fine particle recovery. Since flotation is a continuous process, in this work, the effects of operating parameters on the entrainment of ash materials in a sample coal flotation is investigated from a time-sequence viewpoint. The effects of th...