Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with life-threatening cerebral oedema and dysmyelination in affected individuals. Treatment requires life-long dietary restriction and monitoring of branched-chain amino acids to avoid brain injury. Despite careful management, children commonly suffer metabolic decompensation in the cont...

Timothy M. Crowder, PhD, is chief technology officer at Oriel Therapeutics, Inc., PO Box 14087, Research Triangle Park, NC 27709, tel. 919.313.1290 ext. 11, fax 919.313.1295, [email protected]. ctive dry-powder inhalers (DPIs) for pulmonary drug delivery have been under development for at least 10 years, but to date no such device has been approved by FDA. Like propellant-driven me...

OBJECTIVE The primary objective was to assess the warming sensation caused by IFF Flavour 316282 in a syrup used for short-term treatment by patients suffering from nasal congestion and mild to moderate body pain, headache, fever or sore throat associated with an upper respiratory tract infection. METHODS A single cohort, single treatment arm, open-label study. Subjects received one 30 mL dos...