based on the molecular modeling studies on two major families of anxiolytics and sedative hypnotics (benzodiazepines and barbiturates) a series of phthalimide derivatives were prepared from corresponding di-methyl phthalate derivatives in two steps, namely trans-amidification and ring closer of di-methyl phthalate with urea and base catalysed condensation of 4-bromobenzyl chloride and benzoyl c...

this study presents the influence of hydroxypropyl-β-cyclodextrin (hpbcd) on the aqueous solubility of acyl esters of cyproterone. first, a number of esters of cyproterone were synthesized. then the phase solubility analysis of the compounds in the presence of hpbcd was investigated in phosphate buffer solution at a ph of 7.4. to gain a better understanding of the complexation mechanism, the sy...

this research was conducted to estimate the amount of microbial protein synthesis in iranian buffaloes' rumen. four male swamp buffaloes with average live body weight of 140±10 kg were used in this study. four diets of 0 (control diet, 100% forage), 15, 30 and 45% concentrate in a 4 × 4 latin square were tested. the results indicated that by increasing the concentrate level in the diet of swamp...

some n¬-acyl-n'-aryl thiourea derivatives 4(a-f) have been prepared by the reaction of acyl halides ammonium thiocyanate and aryl amines. the structures of synthesized compounds have been characterized by ir, 1hnmr spectral studies. the synthesized compounds 5(a-f) have been screened for antibacterial activity. the effect of the structure of the investigated compounds on the antibacterial activ...

cancer is a major global problem and is the second leading cause of mortality in the developed countries.resistance to current chemotherapeutics and high incidence of adverse effects are the two principal reasons for developing new anticancer agents. phenylacetamide derivatives can act as potential anticancer agents. synthesis and screening of 2-(4-fluorophenyl)-n-phenylacetamide derivatives in...

abstract human blood and blood products is the source of a wide range of medicinal products used for the treatment and prevention of a variety of injuries and disease. despite stringent routine measures and filters employed, residual pathogen infectivity remains an important challenge in the field of blood transfusion. in this article various measures and technologies that can be applied in ord...

sucrose is applied as an efficient catalyst for the three-component reaction consisting of aromatic aldehydes, malononitrile and resorcinol in a mixture of water and ethanol media as green solvents. the advantages of this method are excellent yeild, inexpensive catalyst and more environmentally friendly. mechanistic insight into the synthesis of 2-amino-4h-chromene included spectral kinetics ap...

There has been special interest in the chemistry of quinolone and pyrimidine derivatives due to their diverse biological activities such as anticonvulsant, anti-malarial agents, antibacterial, antiviral, cytostatic, antithelemintic, antigenotoxic, anti-cancer agents. These compounds are also used as targeting delayed-type hypersensivity and anti-convulsant agents. As a part of our research work...