OBJECTIVE To determine the effect of estradiol treatment on serum corticosterone levels in Oophorectomized (OVX) female Sprague Dawley rats exposed to chronic restraint stress. STUDY DESIGN Experimental study. PLACE AND DURATION OF STUDY Department of Physiology, Army Medical College, Rawalpindi and National Institute of Health, Islamabad, from January to December 2008. METHODOLOGY A tota...

Non-invasive and simultaneous recording of gastrointestinal (GI) activity during stress induction is still an unexplored field. In our previous investigation, the stress-induced alteration tract was explored in rats. Our aims were to expand rat experiment induce response rats (Study 1) humans 2) detect GI activity, heart rate body temperature. preclinical sample, acute induced by immobilization...

The amount of DNA per nucleus in the adrenal medulla cells of four different strains of rats (Wistar, Sprague-Dawley, Long-Evans, and Italico) is determined both under control conditions and after 300 hr of intermittent exposure to cold. The adrenal medulla nuclei of the four strains of rats contain the same amount of DNA; however, the loss of DNA observed after the same experimental treatment ...

This study was carried out to determine the effects of subchronic thinner inhalation on oxidant− antioxidant balance,the relation between toxicity and oxidative stress, a possible protective effect α-lipoic acid against toxicationin rats. Sprague−Dawley rats were divided into 4 groups as follows: control (Gr. I), safranal II), III), andthinner+safranal Gr. IV). Each group consisted 10 rats, las...

The aim of the present study was to investigate toxic effects aluminum chloride (AlCl3) on reproductive organs, as well as, protective effect propolis against AlCl3-induced toxicity in male rats. Eighty adult fertile Sprague Dawley albino rats were randomly divided into four groups 20 each. Group 1: served control group and received only distilled water. 2: a daily ingestion 80 mg/kg AlCl3. 3: ...

The proton-coupled amino acid transporter, PAT1, is known to be responsible for intestinal absorption drug substances such as gaboxadol and vigabatrin. aim of the present study was investigate, if 17-α-ethinyl-estradiol (E-E2) 17-β-estradiol (E) inhibit PAT1-mediated proline taurine in vitro Caco-2 cells vivo using Sprague-Dawley rats assess potential taurine-drug interactions. E E-E2 inhibited...

The effect of acute arterial hypertension on proximal tubular fluid reabsorption was investigated in Sprague-Dawley rats and spontaneously hypertensive rats (SHR) by measuring proximal tubular flow with a nonobstructive optical method. Under control conditions, spontaneous tubular flow was oscillating at 0.02-0.03 Hz in Sprague-Dawley rats. Acute hypertension induced an immediate increase of me...

To support our contention that the Wistar-Furth rat is resistant to mineralocorticoid hypertension, we assessed the effects of deoxycorticosterone (DOC) administration or renal artery stenosis on the development of hypertension in the Sprague-Dawley and Wistar-Furth rat strains. Weekly administration of mineralocorticoid in the form of DOC pivalate resulted in rapid, severe hypertensive cardiov...

In double transgenic rats (dTGR) harboring the human angiotensinogen (hAOGEN) and human renin (hREN) genes, we studied cardiac transcript levels of hypertrophy-related, Ca(2+) regulatory, and beta-adrenoceptor-associated proteins. The contractile properties and the cellular signaling of isolated hearts exposed to (-)isoproterenol and/or angiotensin (Ang) I were evaluated. dTGR developed hyperte...

The effect of acute arterial hypertension on proximal tubular fluid reabsorption was investigated in Sprague-Dawley rats and spontaneously hypertensive rats (SHR) by measuring proximal tubular flow with a nonobstructive optical method. Under control conditions, spontaneous tubular flow was oscillating at 0.02-0.03 Hz in Sprague-Dawley rats. Acute hypertension induced an immediate increase of me...