However, if we obtain the same value, this does not necessarily mean that it is the most accurate one. We thank the Association pour la Recherche en Médecine Foetale for financial support and all of the manufacturers who contributed software packages. We also thank Lau-rence Bussière, who was involved in the early stages of this work. diagnosis of diverse chromosome abnormalities in a populatio...

Beat to beat and day to day variation in computer calculated electrocardiographic measurements is described on the basis of a study of normal serial 3 orthogonal lead electrocardiograms recorded on 25 patients. The variation of scalar amplitudes and vector orientations was investigated for both the QRS complex and the ST-T segment. The 96 per cent ranges of beat to beat and day to day variation...

In intervention and observational studies, it is necessary to determine the number of blood samples required to estimate the true value of Fe-status measures. The aim of the present study was to determine the number of days for blood sampling required in order to measure the 'true value' of five Fe-status parameters in young Fe-depleted women and to investigate the effect of menstrual cycle on ...

To determine the total day-to-day intraindividual variability of ferritin and transferrin receptor (TfR), we collected venous serum and plasma and capillary serum and plasma samples during 10 nonconsecutive days over a 4-wk period from a group of healthy men (n = 10) and women (n = 11) aged 19-46 y. On the basis of a method previously established in younger and older adults, biological (sigma 2...

As any jet-setter knows, it takes time to adapt to the shifted day-night cycle of a foreign time zone. We have an internal circadian clock that times many physiological and behavioral events on a 24-hour cycle, according to day length. The clock can also reset itself, so we can cope with the seasonal variation in day light hours and the trappings of 20th century living such as shift work and ai...