The study of neutrinoless double beta decay (DBD) is the only presently known approach to the fundamental question if the neutrino is a Majorana particle, i.e. its own anti-particle. The observation of neutrinoless DBD would not only establish the Majorana nature of the neutrino but also allow to determine its effective mass if the nuclear matrix elements are given. The status of experiments un...

Aims of study: Diabetic bladder dysfunction (DBD), a collective description of clinical symptoms including decreased sensation, increased capacity, poor emptying, and also detrusor overactivity, is among the most common and costly complications of diabetes mellitus (DM). It is estimated that DBD occurs in approximately 87% of individuals diagnosed with DM, and substantially affects quality of l...

Steroid hormone receptors and signal transducers and activators of transcription (STAT) factors constitute two distinct families of transcription factors activated by different signaling pathways. In previous reports, cross-talk between STAT5 and several steroid receptors has been demonstrated. We investigated putative cross-talk between ERalpha and ERbeta and STAT5. ERalpha and ERbeta were fou...

Lack of p53 expression or expression of mutant p53 is common in human cancers and is associated with increased tumor growth and resistance to therapies. Significant efforts toward pharmaceutical reactivation of defective p53 by small molecules are therefore underway, targeting the different means that inactivate p53. Indeed, reactivated p53 can lead to tumor destruction. A recent paper in Cance...

Internet is a platform which is mostly used to spread malicious software and viruses on the network. The drive by download (DBD) is most successful and popular attack invented by web site attacker till date. Drive by download attack enables the victims to click coded malicious links and the browser will be redirected to malicious web sites to exploit vulnerabilities, and also it installs softwa...

The structures of DNA-protein complexes have illuminated the diversity of DNA-protein binding mechanisms shown by different protein families. This lack of generality could pose a great challenge for predicting DNA-protein interactions. To address this issue, we have developed a knowledge-based method, DNA-binding Domain Hunter (DBD-Hunter), for identifying DNA-binding proteins and associated bi...

Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular ins...

BACKGROUND Carcinoid tumors rarely arise in the extrahepatic bile duct and can be difficult to distinguish from carcinoma. There are no reports of clear cell carcinoid (CCC) tumors in the distal bile duct (DBD) to the best of our knowledge. Herein, we report a CCC tumor in the DBD and review the literature concerning extrahepatic bile duct carcinoid tumors. CASE PRESENTATION A 73-old man pres...

Gene expression is primarily regulated by cis-regulatory DNA elements and trans-interacting proteins. Transcription factors bind in a DNA sequence-specific manner and recruit activities that modulate the association and activity of transcription complexes at specific genes. Often, transcription factors belong to families of related proteins that interact with similar DNA sequences. Furthermore,...

We have developed a method of biochemical patterning which allows for micro and nano-scale resolution on non-planar substrates. In this method, bio molecules (including DNA) are delivered to charged locations on surfaces by charged water buffer droplets. Charging of water droplets is accomplished using Dielectric Barrier Discharge (DBD) plasma. DBD was effectively stabilized in the presence of ...