Developing cotton (Gossypium hirsutum) fibers, cultured in vitro with their associated ovules, were used to compare the effects of two herbicides that inhibit cellulose synthesis: 2,6-dichlorobenzonitrile (DCB) and an experimental thiatriazine-based herbicide, CGA 325'615. CGA 325'615 in nanomolar concentrations or DCB in micromolar concentrations causes inhibition of synthesis of crystalline c...

Two different markers for quantitating cell proliferation were evaluated in livers of control and chemically treated mice and rats. Proliferating cell nuclear antigen (PCNA), an endogenous cell replication marker, and bromodeoxyuridine (BrdU), an exogenously administered DNA precursor label, were detected in formalin-fixed, paraffin-embedded tissues using immunohistochemical techniques. The per...

As a cell source with large quantity and easy access, peripheral blood mesenchymal stem cells (PBMSCs) were isolated and seeded in porcine demineralized cancellous bone (DCB) scaffolds, cultured in chondrogenic medium and evaluated for in vitro chondrogenesis. Bone marrow MSCs (BMMSCs) and articular cartilage chondrocytes (ACCs) underwent the same process as controls. The morphology, viability ...

Developing cotton (Gossypium hirsutum) fibers, cultured in vitro with their associated ovules, were used to compare the effects of two herbicides that inhibit cellulose synthesis: 2,6-dichlorobenzonitrile (DCB) and an experimental thiatriazinebased herbicide, CGA 3259615. CGA 3259615 in nanomolar concentrations or DCB in micromolar concentrations causes inhibition of synthesis of crystalline ce...

BACKGROUND AND PURPOSE Neuronal Na(+)/Ca(2+) exchanger plays a relevant role in maintaining intracellular Ca(2+) and Na(+) levels under physiological and pathological conditions. However, the role of this exchanger in excitotoxicity and ischemia-induced neuronal injury is still controversial and has never been studied in the same neuronal subtypes. METHODS We investigated the effects of bepri...

This is a post-hoc analysis of the results Lutonix AV Global Registry (outside United Sates) focusing exclusively on arteriovenous fistulas (AVFs) with inclusion criteria consistent to those IDE trial from States. Device under investigation was drug-coated balloon (DCB). 131 320 subjects met for in analysis. 59.5% (78/131) were male. 50.5% white and 45.7% Asian population. Among exploratory out...

This paper investigates the role of material properties on crack path selection in adhesively bonded joints. First, a parametric study of directionally unstable crack propagation in adhesively bonded double cantilever beam specimens (DCB) is presented. The alternating crack trajectories in specimens of various material systems are simulated using the finite element method and the results indica...

Caspase activation has been shown to be a critical step in several models of neuronal apoptosis such as staurosporine treatment of human neuroblastoma SH-SY5Y cells and potassium deprivation of rat cerebellar granule neurons. One common event is the appearance of caspase-mediated 120-kDa nonerythroid alpha-spectrin breakdown product (SBDP120). Second, inhibitors of the caspase family are effect...

This paper investigates the roles of external loads and specimen geometry on crack path selection in adhesively bonded joints. First, the effect of mixed mode fracture on crack path selection is studied. Using epoxy as an adhesive and aluminum as the adherends, double cantilever beam (DCB) specimens with various T-stress levels are prepared and tested under mixed mode fracture loading. Post-fai...