There are many potential benefits of delayed or deferred cord clamping (DCC) compared with immediate cord clamping (ICC). Increasing placental transfusion by DCC increases neonatal blood volume and improves transitional hemodynamics. DCC may also increase iron stores, reducing childhood anemia and increasing the transfer of stem cells, which may have antiinflammatory neurotropic and neuroprotec...

Applying a Langevin description of the linear sigma model we investigate four different scenarios for the evolution of a disoriented chiral condensate: annealing or quench with initial conditions governed by effective ‘light’ or physical mass pions. We present pion number distributions estimated from the zero mode (i.e. k = 0-field) component. The best DCC signal is expected for the quench scen...

The experimental observation of disoriented chiral condensate is affected due to various physical and detector related effects. We study and quantify the strength of the experimental signal, “neutral pion fraction” within the framework of a simple DCC model, using the analysis methods based on the multiresolution discrete wavelet technique and by evaluating the signal to background ratio. The s...

Social networks change the way users relate on the Web. One type of social network is the virtual community, which has a social structure that connects citizens and the government. Integrating consultation and deliberative environments for popular participation in democratic issues and creating virtual communities to enhance member relationships makes it possible to model decision-making proces...

This paper presents a methodology for supporting the moderation phase in DCC (Democratic Citizenship Community), a virtual community for supporting e-democratic processes in e-life systems and applications. Based on the Government-Citizen Interactive Model, the DCC encompasses an innovative debate structure, as well as the moderator’s participation based on Discourse Theory, specially concernin...

Netrin-1 is a guidance cue that can trigger either attraction or repulsion effects on migrating axons of neurons, depending on the repertoire of receptors available on the growth cone. How a single chemotropic molecule can act in such contradictory ways has long been a puzzle at the molecular level. Here we present the crystal structure of netrin-1 in complex with the Deleted in Colorectal Canc...

During development, axons migrate long distances in responses to attractive or repulsive signals that are detected by their growth cones. One of these signals is mediated by netrin-1, a diffusible laminin-related molecule that both attracts and repels growth cones via interaction with its receptor DCC (deleted in colorectal cancer). Here we show that DCC in both commissural neurons and immortal...

Cell differentiation is associated either with a complete loss of proliferative potential or with a change in growth requirements. Neoplastic transformation may result from the activation of oncogenes that support growth or from inactivation or loss of tumor suppressor genes, which are thought to regulate differentiation. To examine the relationship between tumor suppressor genes and cell diffe...

Extracellular cues direct axon extension by regulating growth cone morphology. The netrin-1 receptor deleted in colorectal cancer (DCC) is required for commissural axon extension to the floor plate in the embryonic spinal cord. Here we demonstrate that challenging embryonic rat spinal commissural neurons with netrin-1, either in solution or as a substrate, causes DCC-dependent increases in grow...