Objective Thyroid cancer (TC) is one of the fastest-growing malignant tumors. This study sought to explore mechanism immune escape mediated by receptor tyrosine kinase (KIT) in TC. Methods The expression microarray TC was acquired through GEO database, and difference analysis Kyoto encyclopedia genes genomes pathway enrichment were carried out. KIT levels cell lines (K1/SW579/BCPAP) human norma...

Several anti-cancer drugs are known to have immunomodulatory effects, including immunogenic cell death (ICD) of cancer cells. ICD is a form apoptosis which caused by the release damage-associated molecular patterns (DAMPs), uptake antigens dendritic cells, and activation acquired immunity against was originally reported in solid tumors, there been few reports on multiple myeloma (MM). Here, we ...

Death-receptor-mediated signaling results in either cell death or survival. Such opposite cascades emanate from receptor-associated complexes, which are often formed different subcellular locations. The proteins involved frequently post-translationally modified (PTM) by ubiquitination, phosphorylation, glycosylation to allow proper spatio-temporal regulation/recruitment of these complexes a def...

Micro-vascular complications such as diabetic nephropathy (DN) develop in patients with uncontrolled T1DM. Low density lipoprotein receptor-related protein 5 (LRP5) is the co-receptor ligand of Wnt signaling pathway. Many single nucleotide variants have been identified human LRP5 gene and were reported to be associated metabolic disorders. The Wnt/β-catenin pathway has proposed play an importan...

Evasion of death receptor ligand-induced apoptosis represents an important contributor to cancer development and progression. Therefore, molecules that restore sensitivity to death receptor stimuli would be important tools to better understand this biological pathway and potential leads for therapeutic adjuncts. Previously, the small-molecule 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide (th...

Exposure to environmental tobacco smoke has been epidemiologically linked to heart disease among nonsmokers. However, the molecular mechanism behind the pathogenesis of cardiac disease is unknown. In this study, we found that Wistar rats, exposed to tobacco cigarette smoke at doses of 5, 10, or 15 cigarettes for 30 min twice a day for 1 month, had a dose-dependently reduced heart weight to body...

JNK contributes to TNF␣-mediated apoptosis remains Molecular and Cellular Biology to be addressed. Baylor College of Medicine The intrinsic apoptotic pathway is the result of activa-Houston, Texas 70030 tion of mitochondria-mediated cell death events, including changes in mitochondrial membrane permeability and subsequent release of proapoptotic factors in-Summary volved in various aspects of a...