Whereas RBC transfusion therapy is lifesaving in thalassemia, obligatory iron loading accompanies such treatment and chelation therapy to remove and detoxify iron resulting from these chronic transfusions must therefore be administered. Morbidity and mortality in thalassemia is linked closely to the adequacy of chelation. Three chelators are currently available worldwide-deferoxamine, deferasir...

Sanna Kotisaari,* Jarkko Romppanen,* Ulla Ågren,° Sakari Eskelinen,* Kari Punnonen* *Department of Clinical Chemistry, Kuopio University Hospital, PL 1777, Kuopio; °Students’ Health Service, Kuopio University, PL 1777, 70211 Kuopio, Finland

Shewanella sp. CP20 is a marine bacterium that survives ingestion by Tetrahymena pyriformis and is expelled from the protozoan within membrane-bound vacuoles, where the bacterial cells show long-term survival. Here, we report the draft genome sequence of Shewanella sp. CP20 and discuss the potential mechanisms facilitating intraprotozoan survival.

Iron is a limiting nutrient for Symbiodiniaceae (colloquially known as zooxanthellae), with low solubility in seawater. The use of stable, soluble, and chemically defined iron complexes proposed strategy to control the supply this metal target organisms. In work, we investigated effect iron(II) derivatives iron(III) (desferrioxamine, deferiprone, deferasirox, HBED) over growth loading five spec...