Several recent studies demonstrate the potential of using tubular structures such as vessels as a basis for image registration. In this paper, we present a novel technique for the deformable registration of tubular structures. Our approach aligns tubular models, e.g. vessels of an organ, with an image by combining both rigid and non-rigid transformations in a hierarchical manner. The physical s...

Image-based deformations are generally used to align images of deformable objecys moving in the 3D space. For the registration of deformable objects, this assumption has shown to give good results. However it is not satisfying for the registration of images of 3D rigid objects as the underlying structure cannot be directly estimated. The general belief is that obtaining the 3D structure directl...

PURPOSE To develop a statistical sampling procedure for spatially-correlated uncertainties in deformable image registration and then use it to demonstrate their effect on daily dose mapping. METHODS Sequential daily CT studies are acquired to map anatomical variations prior to fractionated external beam radiotherapy. The CTs are deformably registered to the planning CT to obtain displacement ...

PURPOSE For patients undergoing external beam radiation therapy (EBRT) and brachytherapy, recommendations for target doses and constraints are based on calculation of the equivalent dose in 2 Gy fractions (EQD2) from each phase. At present, the EBRT dose distribution is assumed to be uniform throughout the pelvis. We performed a preliminary study to determine whether deformable dose distributio...