Retinoic acid (RA) induces secretory differentiation in the wound epidermis of a regenerating amphibian limb. We investigated the role of individual RA receptor (RAR) types in the newt wound epidermis by introducing chimaeric RA/thyroid hormone (T3) receptors (chi alpha 1 and chi delta 1) that can be activated by T3. A biolistic particle delivery system was employed to transfect cells in the wo...

Tertiary folding of the 160-nt P4-P6 domain of the Tetrahymena group I intron RNA involves burying of substantial surface area, providing a model for the folding of other large RNA domains involved in catalysis. Stopped-flow fluorescence was used to monitor the Mg2+-induced tertiary folding of pyrene-labeled P4-P6. At 35 degrees C with [Mg2+] approximately 10 mM, P4-P6 folds on the tens of mill...

Building upon recent results of Dubédat [7] on the convergence topological correlators in double-dimer model considered Temperleyan approximations $\Omega^\delta$ to a simply connected domain $\Omega\subset\mathbb C$ we prove probabilities cylindrical events for loop ensembles as $\delta\to 0$. More precisely, let $\lambda_1,\dots,\lambda_n\in\Omega$ and $L$ be macroscopic lamination $\Omega\se...

BACKGROUND Inositol 1,4,5trisphosphate (IP(3)) and diacylglycerol (DAG) are important intracellular signalling molecules in various tissues. They are generated by the phospholipase C family of enzymes, of which phospholipase C delta (PLCD) forms one class. Studies with functional inactivation of Plcd isozyme encoding genes in mice have revealed that loss of both Plcd1 and Plcd3 causes early emb...

hGSTA3-3 (human Alpha-class glutathione transferase 3-3) efficiently catalyses steroid Delta(5)-Delta(4) double-bond isomerization in vitro, using glutathione as a cofactor. This chemical transformation is an obligatory reaction in the biosynthesis of steroid hormones and follows the oxidation of 3beta-hydroxysteroids catalysed by 3beta-HSD (3beta-hydroxysteroid dehydrogenase). The isomerizatio...

Yangtze River Delta region in China is rich in port resources. "To prosper city according to ports" has become one of the strategies of promoting economy development. Therefore, the development of port logistics has a very important position in Yangtze River Delta region economy development. This paper sets up a new evaluation index system for port logistics efficiency and effectiveness evaluat...

In addition to xeroderma pigmentosum, mutations in the human XPG gene cause early onset Cockayne syndrome (CS). Here, we provide evidence for the involvement of RAD2, the S. cerevisiae counterpart of XPG, in promoting efficient RNA polymerase II transcription. Inactivation of RAD26, the S. cerevisiae counterpart of the human CSB gene, also causes a deficiency in transcription, and a synergistic...

Aortic pulse wave velocity (PWV), a measure of aortic stiffness, is an important indicator of cardiovascular risk. Derivation of PWV from uncalibrated proximal aortic or carotid pressure alone has practical advantages. However, when the time of return of the reflected wave, (Delta)t, is used to calculate PWV, inaccurate data are obtained. With aging PWV increases but (Delta)t hardly decreases, ...

The double impulse is introduced as a substitute of the fling-step near-fault ground motion. A closed-form solution of the elastic–plastic response of a structure on compliant (flexible) ground by the “critical double impulse” is derived for the first time based on the solution for the corresponding structure with fixed base. As in the case of fixed-base model, only the free vibration appears u...

Abstract Recently, it was demonstrated that a modification of the Kalman-filtering model with pointwise delay signal noise could improve communication considerably distanced spacecraft. However, complete and correct derivation equations Kalman-type filter for this case has not yet been provided. In paper, we close gap. The method is based on passage from distributed to by means delta function. ...