Multiple sclerosis, an inflammatory, demyelinating disease of the CNS currently lacks an effective therapy. We show here that CNS inflammation and clinical disease in experimental autoimmune encephalomyelitis, an experimental model of multiple sclerosis, could be prevented completely by a replication-defective adenovirus vector expressing the anti-inflammatory cytokine IL-10 (replication-defici...

The mechanisms underlying the initiation of virus-induced autoimmune disease are not well understood. Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a mouse model of multiple sclerosis, is initiated by TMEV-specific CD4(+) T cells targeting virally infected central nervous system-resident (CNS-resident) antigen-presenting cells (APCs), leading to chronic acti...

The diagnosis and treatment of central nervous system (CNS) idiopathic inflammatory demyelinating diseases have been recurrently reviewed over the past two decades. In this group of diseases, Multiple Sclerosis (MS) is the most frequent CNS pathology. However, MS diagnosis requires a systematic exclusion of alternative diagnoses. Our objective with this review is to help standardize and optimiz...

Objective To assess the frequency of spinal cord central canal dilation on magnetic resonance imaging (MRI) in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) myelitis compared to aquaporin-4-positive-neuromyelitis optic spectrum disorder (AQP4+NMOSD) and multiple sclerosis (MS). Background In MOGAD myelitis, a sagittal T2-hyperintense line accompanied by a...

The complexity and organization of the central nervous system (CNS) is widely modulated by presence blood–brain barrier (BBB) blood–cerebrospinal fluid (BCSFB), which both act as biochemical, dynamic obstacles impeding any type undesirable exogenous exchanges. disruption these barriers usually associated with development neuropathologies can be consequence genetic disorders, local antigenic inv...

This review will examine various infectious parameters that could lead to enhancement or exacerbation of autoimmune disease. Multiple sclerosis (MS) will be the prototype human autoimmune disease detailed and experiments relating to the pathogenesis of MS will use data derived from an experimental animal model, experimental allergic encephalomyelitis (EAE). Other autoimmune diseases will be inc...

Multiple sclerosis (MS) is an autoimmune CNS demyelinating disease in which infection may be an important initiating factor. Pathogen-induced cross-activation of autoimmune T cells may occur by molecular mimicry. Infection with wild-type Theiler's murine encephalomyelitis virus induces a late-onset, progressive T cell-mediated demyelinating disease, similar to MS. To determine the potential of ...

Transverse myelitis (TM) is a clinical syndrome in which an inflammatory process causes neuronal damage to the spinal cord, leading varying degrees of muscle weakness, sensory changes, and autonomic dysfunction. MT can be form presentation multi-focal CNS disease, multi-systemic, infectious, paraneoplastic, demyelinating, autoimmune or idiopathic disease.The purpose research was analyze cases t...

The laboratory examination of cerebrospinal fluid (CSF) continues to play an important role in the clinical diagnosis and treatment of various disorders of the central nervous system (CNS). The major conditions currently include, as they have in the past, infectious diseases, neoplastic processes, multiple sclerosis, other demyelinating disorders, and intracerebral hemorrhage. Recent publicatio...