Perpetuation of immune deficiency throughout tumor development is, to a great degree, the result of impairment of dendritic cell function by products secreted by tumors. They include cytokines, non-tumor-specific molecules (gangliosides, prostanoids, nitric oxide, etc.) and tumor-(specific) antigens (MUC-1, PSA, Her-2 neu). They may engender a distortion of dendritic cell development, block den...

Introduction: Ovarian hyper-stimulation is widely used in IVF clinics. The main purpose of this method is to stimulate folliculogenesis and increase the number of oocytes in one cycle. Following ovarian hyper-stimulation, hormonal secretion of the ovary, particularly estradiol and progesterone dramatically increases. Immune cells especially dendritic cells have receptors for the estradiol...

Human blood dendritic cells require UV-B radiation (290 to 320 nm) in excess of 1,000 J/m2 to inhibit their stimulation of primary T-cell responses to alloantigen by 60% to 70% or more. The effect is twofold to threefold greater in the allogeneic mixed leukocyte reaction (MLR) than in polyclonal mitogenesis using comparable numbers of dendritic cells and doses of UV-B radiation. UV-B radiation ...

In this review, we explore the role of dendritic cell subsets in the development of tissue-specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is becoming clear that we are only at the beginning of understanding the role of these antigen presenting cells in mediating autoimmunity. Emerging research areas for the study of dendritic cell involvement in the onse...