نتایج جستجو برای: dense granule antigen
تعداد نتایج: 292316 فیلتر نتایج به سال:
The present study demonstrates that the subcutaneous administration of Neospora caninum dense granule protein 7 (NcGRA7) entrapped in liposomes coated with mannotriose strongly induces the parasite-specific T-helper type 1 immune response and humoral antibody in mice. Although anti-NcGRA7 immunoglobulin G1 antibody production was induced in mice injected with NcGRA7 alone, the dams and offsprin...
Patients with platelet α or dense δ-granule defects have bleeding problems. Although several proteins are known to be required for δ-granule development, less is known about α-granule biogenesis. Our previous work showed that the BEACH protein NBEAL2 and the Sec1/Munc18 protein VPS33B are required for α-granule biogenesis. Using a yeast two-hybrid screen, mass spectrometry, coimmunoprecipitatio...
Exposure of horse platelets to thrombin has been reported to cause nearly complete inactivation of cyclooxygenase within 30 sec. This contrasts with the observation that human platelets. depleted of their granule constituents by stimulation with thrombin. still aggregate in response to arachidonic acid, a reaction presumably mediated by thromboxane A2 (TxA2) formation. Because of this conflicti...
effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. as a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. the fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose con...
Under the electron microscope various substructures were observable in the attenuated cytoplasm of platelets without any treatment, i.e., fixation, embedding or staining. The granulomere of platelets revealed dense bodies of 200-300nm diameter and smaller dense granules (about 50nm). Larger ovoid bodies with dense granules presumably corresponded to mitochondria and lysosomes. In the hyalomere ...
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