With the rising importance of proteomics research, current experimental methods of protein structure determination are too slow to map the millions of protein interactions observed in humans. In an effort to remedy this problem, computational methods of protein modeling are being developed. Changes in protein energetic and structural properties, caused by pH, are key to many interactions within...

One of the major challenges in nanomedicine is to improve nanoparticle cell selectivity and adhesion efficiency through designing functionalized nanoparticles of controlled sizes, shapes, and material compositions. Recent data on cylindrically shaped filomicelles are beginning to show that non-spherical particles remarkably improved the biological properties over spherical counterpart. Despite ...

In any distributed computing environment, performance optimization, job runtime predictions, or capacity and scalability quantification studies are considered as being rather complex, time-consuming and expensive while the results are normally rather error-prone. Based on the nature of the Hadoop MapReduce framework, many MapReduce production applications are executed against varying data-set s...

This work describes a method for generating back-off models for context-dependent unit modeling. The main characteristic of the approach is that of building generic models by gathering statistics of detailed models, collected during BaumWelch reestimation. The construction of back-off models does not require additional processing of the training data, allowing to quickly build different models ...

A voltage-dependent diffused resistor model has been developed using conventional voltage controlled current sources (VCCS’s) defined by a two-dimensional polynomial for simulations of mixed-signal circuits. The polynomial coefficients can be defined by a simple firstorder polynomial which can be a function of geometry and process variables to accurately reflect the manufacturing process. Alter...

Copper electroplated profiles exhibit pattern dependent topography. We propose a methodology for the characterization and modeling of feature scale copper step heights and the height of copper array regions, as a function of layout parameters. The resulting empirical models with parameters extracted from conventional and super fill plating processes capture several key trends important in elect...

Inactivation of many ion channels occurs through largely voltage-independent transitions to an inactivated state from the open state or from other states in the pathway leading to opening of the channel. Because this form of inactivation is state-dependent rather than voltage-dependent, it cannot be described by the standard Hodgkin-Huxley formalism used in virtually all modeling studies of neu...

DEMIRCIOGLU, HARUN. Modeling Layout Dependent Stress Effects for CMOS. (Under the direction of Dr. W. Rhett Davis.) Process induced mechanical stress has enabled continued CMOS scaling since the 90nm node to improve carrier transport and maintain high drive current. This stress depends strongly on the layout shape as well as the surroundings of each transistor in a circuit. The resulting stress...

In spoken dialogue systems, hyperarticulation occur as an e ect to recover previous recognition errors. It is commonly observed that in particular real users apply similar recovery strategies as in human-human interactions. Previous studies have shown that current speech recognizer cannot handle hyperarticulated speech. As an e ect of higher word error rates at hyperarticulated speech, humans t...

Hysteresis of a piezoelectric actuator is ratedependent. Most hysteresis models are based on elementary rate-independent operators and are not suitable for modeling actuator behavior across a wide frequency band. This work proposes a rate-dependent modified PrandtlIshlinskii (PI) operator to account for the hysteresis of a piezoelectric actuator at varying frequency. We have shown experimentall...